Product - excision nuclease
Product excision nuclease
EC#: Encoded By: uvrA
UvrA is "a molecular matchmaker" and damage-specific DNA-binding protein. Complexes with UvrB as A2B1 complex, delivers B to the damage site and dissociates from the UvrB-DNA complex (Selby&Sancar,1993,JBact 175:7509)References:
- Allan, J.M., M.N. Routledge, R.C. Garner 1996. The Escherichia coli DNA repair protein UvrA can re-associate with the UvrB: aflatoxin B1-DNA complex in vitro. Mutat.Res. 362:261-268
- Tomer, G., O. Cohen-Fix, M.A. O'Donnell, M. Goodman, Z. Livneh 1996. Reconstitution of repair-gap UV mutagenesis with purified proteins from Escherichia coli: a role for DNA polymerases III and II. Proc.Natl.Acad.Sci.USA 93:1376-1380
- Moolenaar, G.F., V. Monaco, G.A. van der Marel, J.H. van Boom, R. Visse, N. Goosen 2000. The effect of the DNA flanking the lesion on formation of the UvrB-DNA preincision complex.Mechanism for the UvrA-mediated loading of UvrB onto a DNA damaged site.
- Goosen, N., G.F. Moolenaar 2001. Role of ATP hydrolysis by UvrA and UvrB during nucleotide excision repair. Res.Microbiol. 152:401-409