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Product O6-methylguanine-DNA methyltransferase, inducible
| O6-methylguanine-DNA methyltransferase, inducible |
| transcription factor, Class I |
requires C-terminal region of RNA polymerase alpha for transcription activation. transfers O6-MeG or O4-MeT to Cys321 of Ada methyltransferase itself and Me-P-triester Me grp. to Cys69., converting Ada to transcriptional activator of ada-alkB,alkA,aidB.
- Sakumi, K., K. Igarashi, M. Sekiguchi, A. Ishihama 1993. The Ada protein is a Class I transcription factor of Escherichia coli. J.Bacteriol. 175:2455-2457
- Myers, L.C., T.D. Cushing, G. Wagner, G.L. Verdine 1994. Metal-coordination sphere in the methylated Ada protein-DNA co-complex. Chem. Biol. 1:91-97
- Wibley, J.E., J.H. McKie, K. Embrey, D.S. Marks, M.H. Moore, P.C. Moody 1995. A homology model of the three-dimensional structure of human O6-alkylguanine-DNA alkyltransferase based on the crystal structure of the C-terminal domain of the Ada protein f
- Sakashita, H., T. Sakuma, Y. Akitomo, T. Ohkubo, M. Kainosho, M. Sekiguchi, K. Morikawa 1995. Sequence-specific DNA recognition of the Escherichia coli Ada protein associated with the methylation-dependent functional switch for transcriptional regulati
- Maynard, A.T., D.G. Covell 2001. Reactivity of zinc finger cores: analysis of protein packing and electrostatic screening. Journal of the American Chemical Society 123:1047-58
- Delaney, J.C., J.M. Essigmann 2001. Effect sequence context on O(6)-methylguanine repair and replication in vivo. Biochemistry 40:14968-14975