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Product toxic membrane polypeptide
| toxic membrane polypeptide |
| Hok (host-killing) protein, homologous to Hok toxins of plasmid R1 |
ca. 50 a.a. Anchored in cytoplasmic memb. by N-terminal part of protein. C-terminal is localized in periplasm in dimeric form with at least one di-S bond. Periplasmic portion is the toxic domain;dimerization req. for toxicity. Collapse of memb.potential.
- Poulsen, L.K., N.W. Larsen, S. Molin, P. Andersson 1989. A family of genes encoding a cell-killing function may be conserved in all gram-negative bacteria. Mol.Microbiol. 3:1463-1472
- Poulsen, L.K., A. Refn, S. Molin, P. Andersson 1991. Topographic analysis of the toxic Gef protein from Escherichia coli. Mol.Microbiol. 5:1627-1637
- Gerdes, K., A.P. Gultyaev, T. Franch, K. Pedersen, N.D. Mikkelsen 1997. Antisense RNA-regulated programmed cell death. Annu.Rev.Genet. 31:1-31