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Product a serine protease, periplasmic, endoprotease
| a serine protease, periplasmic, endoprotease |
DegP and DegQ form dodecamers, large oligomeric complex typical of intracellular proteases. See also DegP protease. DegS and YaeL cleave RseA, allowing activation of sigmaE response to protein misfolding.
- Kolmar, H., P.R. Waller, R.T. Sauer 1996. The DegP and DegQ periplasmic endoproteases of Escherichia coli: specificity for cleavage sites and substrate conformation. J.Bacteriol. 178:5925-5929
- Alba, B.M., J.A. Leeds, C. Onufryk, C.Z. Lu, C.A. Gross 2002. DegS and YaeL participate sequentially in the cleavage of RseA to activate the sigma(E)-dependent extracytoplasmic stress response. Genes Dev. 16:2156-2168