Product cysteine desulfurase
|NifS-like protein catalyzing formation of S and alanine from cysteine|
|sulfurtransferase in tRNA 4-thiouridine synthesis (also req. for 2-thiouridine syn.|
pyridoxal-5'P enzyme. Probably contributes S to Fe-S clusters. Can mobilize S from cysteine and contribute it to [4F3-4S] cluster of dihydroxyacid dehydratase. Promotes repair of NO modified ferredoxin.
- Flint, D.H. 1996. Escherichia coli contains a protein that is homologous in function and N-terminal sequence to the protein encoded by the nifS gene of Azotobacter vinelandii and that can participate in the synthesis of the Fe-S cluster of dihydroxy-ac
- Schwartz, C.J., J.L. Giel, T. Patschkowski, C. Luther, F.J. Ruzicka, H. Beinert, P. Kiley 2001. IscR, an Fe-S cluster-containing transcription factor, represses expression of Escherichia coli genes encoding Fe-S cluster assembly proteins. Proc.Natl.Aca
- Yang, W., P.A. Rogers, H. Ding 2002. Repair of nitric oxide-modified ferredoxin [2Fe-2S] cluster by cysteine desulfurase (IscS). J.Biol.Chem. 277:12868-12873
- Kambampati, R., C.T. Lauhon 2003. MnmA and IscS are required for in vitro 2-thiouridine biosynthesis in Escherichia coli. Biochemistry 42:1109-1117