Site argP
- Name: argP
- Type: Gene
- Synonyms
b2916 MG1655 locus tag iciA inhibitor chromosomal (replication) initiation - Mnemonic: Arginine
- Left End Point: 65.91
- Right End Point: 65.93
- Products:
transport of arginine,ornithine and lysine IciA, inhibitor of initiation of chromosomal replication - Direction: >
- Properties:
Property Comment member of LysR family - Priority: 1
- 3 Alleles of This Gene
argP55 argP768(del)::kan argP794-YFP(::cat) - External Database Links:
Host Site Page Links EcoGene.org EG10490 EcoliWiki argP - Comment:
- Selectable Pheno. Loss: canavanine resistance; thiosine resistance; canavanine & thiouracil resistance. See notes, W.Maas iciA
- References:
- Maas, W.K. 1965. Genetic defect affecting an arginine permease and repression of arginine synthesis in E. coli. Fed.Proc. 24:1239-1242
- Pierard, A., N. Glansdorff, J. Yashphe 1972. Mutations affecting uridine monophosphate pyrophosphorylase or the argR gene in Escherichia coli. Mol.Gen.Genet. 118:235-245
- Slayman? 1973. The genetic control of membrane transport. Curr.Topics Microbiol.Immunol. 4:1-174
- Rosen, B.P. 1973. Basic amino acid transport in Escherichia coli: properties of canavanine-resistant mutants. J.Bacteriol. 116:627-635
- Halsall, D.M. 1975. Strains of E. coli with defective lysine transport systems. Biochem.Genet. 13:109-124
- Hwang, D.S., A. Kornberg 1990. A novel protein binds a key origin sequence to block replication of an E. coli minichromosome. Cell 63:325-331
- Thony, B., D.S. Hwang, L. Fradkin, A. Kornberg 1991. iciA, an Escherichia coli gene encoding a specific inhibitor of chromosomal initiation of replication in vitro. Proc.Natl.Acad.Sci.USA 88:4066-4070
- Hwang, D.S., A. Kornberg 1992. Opposed actions of regulatory proteins, DnaA and IciA, in opening the replication origin of Escherichia coli. J.Biol.Chem. 267:23087-23091
- Hwang, D.S., B. Thony, A. Kornberg 1992. IciA protein, a specific inhibitor of initiation of Escherichia coli chromosomal replication. J.Biol.Chem. 267:2209-2213
- Lee, Y.S., H. Kim, D.S. Hwang 1996. Transcriptional activation of the dnaA gene encoding the initiator for oriC replication by IciA protein, an inhibitor of in vitro oriC replication in Escherichia coli. Mol.Microbiol. 19:389-396
- Celis, R.T. 1999. Repression and activation of arginine transport genes in Escherichia coli K 12 by the ArgP protein. J.Mol.Biol. 294:1087-1095