Site nth
- Name: nth
- Type: Gene
- Synonyms
b1633 MG1655 locus tag - Mnemonic: endonuclease three
- Left End Point: 36.85
- Right End Point: 36.86
- Products:
``endonuclease III" DNA glycosylase/AP(apyrimidine)-lyase - Direction: >
- Properties:
Property Comment encodes endonuclease - Priority: 1
- 3 Alleles of This Gene
nth-1::kan,ble nth-782(del)::kan nth-791-YFP(::cat) - External Database Links:
Host Site Page Links NCBI/GenBank J02857 EcoGene.org EG10662 EcoliWiki nth - Comment:
- ``Endonuclease III''; a DNA glycosylase/AP (apyrimidinic) lyase, rather than a true endonuclease, specific for damaged pyrimidine sites.
- References:
- Cunningham, R.P., B. Weiss 1985. Endonuclease III (nth) mutants of Escherichia coli. Proc.Natl.Acad.Sci.USA 82:474-478
- Weiss, B., R.P. Cunningham 1985. Genetic mapping of nth, a gene affecting endonuclease III (thymine glycol-DNA glycosylase) in Escherichia coli K-12. J.Bacteriol. 162:607-610
- Bailly, V., W.G. Verly 1987. Escherichia coli endonuculease III is not an endonuclease but a beta-elimination catalyst. Biochem.J. 242:565-572
- Roldan-Arjona, T., B. Sedgwick 1996. DNA base damage induced by ionizing radiation recognized by Escherichia coli UvrABC nuclease but not Nth or Fpg proteins. Mol. Carcinog. 16:188-196
- Laval, J. 1996. Role of DNA repair enzymes in the cellular resistance to oxidative stress. Pathol.Biol.(Paris) 44:14-24
- Saito, Y., F. Uraki, S. Nakajima, A. Asaeda, K. Ono, K. Kubo, K. Yamamoto 1997. Characterization of endonuclease III (nth) and endonuclease VIII (nei) mutants of Escherichia coli K-12. J.Bacteriol. 179:3783-3785
- Harrison, L., Z. Hatahet, A.A. Purmal, S.S. Wallace 1998. Multiply damaged sites in DNA: interactions with Escherichia coli endonucleases III and VIII. Nucleic Acids Res. 26:932-941
- Tano, K., Y. Iwamatsu, S. Yasuhira, H. Utsumi, K. Takimoto 2001. Increased base change mutations at G:C pairs in Escherichia coli deficient in endonuclease III and VIII. Journal of Radiation Research 42:409-413