Site serA
- Name: serA
- Type: Gene
- Synonyms
b2913 MG1655 locus tag - Mnemonic: Serine
- Left End Point: 65.86
- Right End Point: 65.88
- Products:
phosphoglycerate dehydrogenase - Direction: <
- Properties:
Property Comment auxotrophy-amino acid NULL - Priority: 1
- 8 Alleles of This Gene
serA0 serA1 serA12 serA24 serA25 serA27 serA6 serA764(del)::kan - External Database Links:
Host Site Page Links NCBI/GenBank N00029 EcoGene.org EG10944 EcoliWiki serA - Comment:
- Selectable phenotype. FBI-: serine hydroxamate resistance.
- References:
- Tosa, T., L.I. Pizer 1971. Biochemical bases for the antimetabolite action of L-serine hydroxamate. J.Bacteriol. 106:972-982
- Tobey, K.L., G.A. Grant 1986. The nucleotide sequence of the serA gene of Escherichia coli and the amino acid sequence of the encoded protein, D-3-phosphoglycerate dehydrogenase. J.Biol.Chem. 261:12179-12183
- O'Day, K., J. Lopilato, A. Wright 1991. Physical locations of bglA and serA on the Escherichia coli K-12 chromosome. J.Bacteriol. 173:1571-0
- Zhao, G., M.E. Winkler 1996. A novel alpha-ketoglutarate reductase activity of the serA-encoded 3-phosphoglycerate dehydrogenase of Escherichia coli K-12 and its possible implications for human 2-hydroxyglutaric aciduria. J.Bacteriol. 178:232-239
- Al-Rabiee, R., Y. Zhang, G.A. Grant 1996. The mechanism of velocity modulated allosteric regulation in D-3-phosphoglycerate dehydrogenase. Site-directed mutagenesis of effector binding site residues. J.Biol.Chem. 271:23235-23238
- Blauwkamp, T.A., A.J. Ninfa 2002. Nac-mediated repression of the serA promoter of Escherichia coli. Mol.Microbiol. 45:351-363