Site alkB
- Name: alkB
- Type: Gene
- Synonyms
aidD b2212 MG1655 locus tag - Mnemonic: Alkylation
- Left End Point: 49.72
- Right End Point: 49.74
- Products:
oxidative demethylase,repair enzyme for alkylated DNA or RNA, an oxoglutarate depend.oxygenase - Direction: <
- Properties:
Property Comment repair system gene NULL - Priority: 1
- 1 Alleles of This Gene
alkB765(del)::kan - External Database Links:
Host Site Page Links EcoGene.org EG10037 EcoliWiki alkB - Comment:
- DNA and RNA repair system specific for alkylated DNA and RNA. Absence (null mutant) leads to extreme sensitivity to killing by MMS.
- References:
- Kataoka, H., H. Yamamoto, M. Sekiguchi 1983. A new gene (alkB) of Escherichia coli that controls sensitivity to methyl methane sulfonate. J.Bacteriol. 153:1301-1307
- Kataoka, H., M. Sekiguchi 1985. Molecular cloning and characterization of the alkB gene of Escherichia coli. Mol.Gen.Genet. 198:263-269
- Kondo, H., Y. Nakabeppu, H. Kataoka, S. Kuhara, S. Kawabata, M. Sekiguchi 1986. Structure and expression of the alkB gene of Escherichia coli related to the repair of alkylated DNA. J.Biol.Chem. 261:15772-15777
- Volkert, M.R., D.C. Nguyen, K.C. Beard 1986. Escherichia coli gene induction by alkylation treatment. Genetics 112:11-26
- Chen, B.J., P. Carroll, L.D. Samson 1994. The Escherichia coli AlkB protein protects human cells against alkylation-induced toxicity. J.Bacteriol. 176:6255-6261
- Wei, Y.-F., B.J. Chen, L.D. Samson 1995. Suppression of Escherichia coli alkB mutants by Saccharomyces cerevisiae genes. J.Bacteriol. 177:5009-5015
- Falnes, P.O., R.F. Johansen, E. Seeberg 2002. AlkB-mediated oxidative demethylation reverses DNA damage in Escherichia coli. Nature 419:178-182
- Begley, T.J., L.D. Samson 2003. AlkB mystery solved: oxidative demethylation of N1-methyladenine and N3-methylcytosine adducts by a direct reversal mechanism. Trends Biochem.Sci. 28:2-5
- Aas, P.A., M. Otterlei, P.O. Falnes, C.B. Vagbo, F. Skorpen, M. Akbari, O. Sundheim, M. Bjoras, G. Slupphaug, E. Seeberg, H.E. Krokan 2003. Human and bacterial oxidative demethylases repair alkylation damage in both RNA and DNA.[comment]. Nature 421:85