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Site era
- Name: era
- Type: Gene
- Synonyms
b2566 MG1655 locus tag - Mnemonic: E.coli ras-like
- Left End Point: 58.21
- Right End Point: 58.23
- Products:
GTP-binding protein - Direction: <
- Properties:
Property Comment essential gene NULL - Priority: 0
- 1 Alleles of This Gene
era-791-YFP(::cat) - External Database Links:
Host Site Page Links NCBI/GenBank M14658 EcoGene.org EG10270 EcoliWiki era - Comment:
- may be chaperone involved in ribosome assembly
- References:
- Ahnn, J., P.E. March, H.E. Takiff, M. Inouye 1986. A GTP-binding protein of Escherichia coli has homology to yeast RAS proteins. Proc.Natl.Acad.Sci.USA 83:8849-8853
- Chen, S.M., H.E. Takiff, A.M. Barber, G.C. Dubois, J.C. Bardwell, D.L. Court 1990. Expression and characterization of RNase III and Era proteins. Products of the rnc operon of Escherichia coli. J.Biol.Chem. 265:2888-2895
- Lerner, C.G., M. Inouye 1991. Pleiotropic changes resulting from depletion of Era, an essential GTP-binding protein in Escherichia coli. Mol.Microbiol. 5:951-957
- Lerner, C.G., P. Sood, J. Ahnn, M. Inouye 1992. Cold-sensitive and decreased GTP-hydrolytic-activity from substitution of Pro17 for Val in Era, an essential Escherichia coli GTPase. FEMS Microbiol.Lett. 95:137
- Sood, P., C.G. Lerner, T. Shimamoto, Q. Lu, M. Inouye 1994. Characterization of the autophosphorylation of Era, an essential Escherichia coli GTPase. Mol.Microbiol. 12:201-208
- Comartin, D.J., E.D. Brown 2006. Non-ribosomal factors in ribosome subunit assembly are emerging targets for new antibacterial drugs. Curr Opin Pharmacol 6:453-458