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Site relA
- Name: relA
- Type: Gene
- Synonyms
b2784 MG1655 locus tag - Mnemonic: Relaxed
- Left End Point: 62.71
- Right End Point: 62.76
- Products:
ATP:GTP 3'-pyrophosphotransferase stringent factor ppGpp synthetase guanosine 3'5'-bispyrophosphate synthetase I - Direction: <
- Properties:
Property Comment regulatory gene NULL - Priority: 1
- 7 Alleles of This Gene
relA0 relA1 relA2 relA41 relA42 relA782(del)::kan relA882(del)::FRT - External Database Links:
Host Site Page Links NCBI/GenBank J04039 EcoGene.org EG10835 EcoliWiki relA - Comment:
- RelA required for synthesis of ppGpp during stringent response to a.a.starvation. in stringent cells, tRNA synthesis is repressed during a.a.starvation.
- References:
- Fiil, N. 1968. Isolation of "relaxed" mutants of Escherichia coli. J.Bacteriol. 95:729-731
- Ramabhadram, T.V. 1976. Method for the isolation of Escherichia coli relaxed mutants, utilizing near-ultraviolet irradiation. J.Bacteriol. 127:1587-1589
- Daniel, J., A. Danchin 1979. Involvement of cyclic AMP and its receptor protein in the sensitivity of Escherichia coli K12 toward serine. Mol.Gen.Genet. 176:343-350
- Metzger, S., I.B. Dror, E. Aizenman, G. Schreiber, M. Toone, J.D. Friesen, M. Cashel, G. Glaser 1988. The nucleotide sequence and characterization of the relA gene of Escherichia coli. J.Biol.Chem. 263:15699-15704
- Metzger, S, G Schreiber, E Aizenman, M Cashel, G Glaser 1989. Characterization of the relA1 mutation and a comparison of relA1 with new relA null alleles in Escherichia coli. J. Biol. Chem. 264(35):21146-52.
- Metzger, S., E. Sarubbi, G. Glaser, M. Cashel 1989. Protein sequences encoded by the relA and the spoT genes of Escherichia coli are interrelated. J.Biol.Chem. 264:9122-9125
- Schreiber, G., S. Metzger, E. Aizenman, S. Roza, M. Cashel, G. Glaser 1991. Overexpression of the relA gene in Escherichia coli. J.Biol.Chem. 266:3760-3767
- Xiao, H, M Kalman, K Ikehara, S Zemel, G Glaser, M Cashel 1991. Residual guanosine 3',5'-bispyrophosphate synthetic activity of relA null mutants can be eliminated by spoT null mutations. J. Biol. Chem. 266(9):5980-90.
- Svitil, A.L., M. Cashel, J.W. Zyskind 1993. Guanosine tetraphosphate inhibits protein synthesis in vivo. A possible protective mechanism for starvation stress in Escherichia coli. J.Biol.Chem. 268:2307-2311
- Goldemberg, S.H. 1994. A role for polyamines in the control of ppGpp levels in Escherichia coli. Cell Mol Biol (Noisy-Le-Grand) 40:899-905
- Goldemberg, S.H. 1996. In vitro studies on ppGpp synthetase I from polyamine-starved and unstarved Escherichia coli. Cell Mol Biol (Noisy-Le-Grand) 42:719-727
- Murray, K.D., H. Bremer 1996. Control of spoT-dependent ppGpp synthesis and degradation in Escherichia coli. J.Mol.Biol. 259:41-57
- Sorensen, M.A. 2001. Charging levels of four tRNA species in Escherichia coli Rel(+) and Rel(-) strains during amino acid starvation: a simple model for the effect of ppGpp on translational accuracy. J.Mol.Biol. 307:785-798
- Gustavsson, N., A. Diez, T. Nystrom 2002. The universal stress protein paralogues of Escherichia coli are co-ordinately regulated and co-operate in the defence against DNA damage. Mol.Microbiol. 43:107-117
- Funabashi, H., T. Haruyama, M. Mie, Y. Yanagida, E. Kobatake, M. Aizawa 2002. Non-destructive monitoring of rpoS promoter activity as stress marker for evaluating cellular physiological status. Journal of Biotechnology 95:85-93