Site marR
- Name: marR
- Type: Gene
- Synonyms
b1530 MG1655 locus tag cfxB soxQ - Mnemonic: multiple antibiotic resistance
- Left End Point: 34.86
- Right End Point: 34.87
- Products:
repressor involved in sensing phenolics negative regulator of marRAB - Direction: >
- Properties:
Property Comment regulatory gene MarR family of repressors may be phenolic sensors - Priority: 0
- 2 Alleles of This Gene
marR11 marR751(del)::kan - External Database Links:
Host Site Page Links NCBI/GenBank M96235 EcoGene.org EG11435 EcoliWiki marR - Comment:
- soxQ1 and cfxB1 reported to be marR alleles by Ariza et al., cited below
- References:
- Cohen, S.P., H. Hachler, S.B. Levy 1993. Genetic and functional analysis of the multiple antibiotic resistance (mar) locus in Escherichia coli. J.Bacteriol. 175:1484-1492
- Ariza, R.R., S.P. Cohen, N. Bachhawat, S.B. Levy, B. Demple 1994. Repressor mutations in the marRAB operon that activate oxidative stress genes and multiple antibiotic resistance in Escherichia coli. J.Bacteriol. 176:143-148
- Rosner, J.L., J.L. Slonczewski 1994. Dual regulation of inaA by the multiple antibiotic resistance (mar) and superoxide (soxRS) stress response systems of Escherichia coli. J.Bacteriol. 176:6262-6269
- Sulavik, M.C., L.F. Gambino, P.F. Miller 1995. The MarR repressor of the multiple antibiotic resistance (mar) operon in Escherichia coli: prototypic member of a family of bacterial regulatory proteins involved in sensing phenolic compounds. Mol.Med. 1:
- Martin, R.G., K.W. Jair, R.E. Wolf, J.L. Rosner 1996. Autoactivation of the marRAB multiple antibiotic resistance operon by the MarA transcriptional activator in Escherichia coli. J.Bacteriol. 178:2216-2223
- Goldman, J.D., D.G. White, S.B. Levy 1996. Multiple antibiotic resistance (mar) locus protects Escherichia coli from rapid cell killing by fluoroquinolones. Antimicrob.Agents Chemother. 40:1266-1269
- Alekshun, M.N., S.B. Levy 1999. Alteration of the repressor activity of MarR, the negative regulator of the Escherichia coli marRAB locus, by multiple chemicals in vitro. J.Bacteriol. 181:4669-4672