Site clpX
- Name: clpX
- Type: Gene
- Synonyms
b0438 MG1655 locus tag LopC - Mnemonic: caseinolytic protease
- Left End Point: 9.84
- Right End Point: 9.87
- Products:
ClpX protease, activator of ClpP - Direction: >
- Properties:
Property Comment encodes a protease alternate protein that activates ClpP regulatory gene NULL encodes chaperone molecule member of multimeric ATPase family; Releases MuA transposase from DNA by transient conformational change in MuA,hence a chaperone - Priority: 0
- 2 Alleles of This Gene
clpX103(del-ins)::kan clpX724(del)::kan - External Database Links:
Host Site Page Links EcoGene.org EG10159 EcoliWiki clpX - Comment:
- References:
- Gottesman, S., W.P. Clark, V. de Crecy-Lagard, M.R. Maurizi 1993. ClpX, an alternative subunit for the ATP-dependent Clp protease of Escherichia coli. Sequence and in vivo activities. J.Biol.Chem. 268:22618-22626
- Wojkowiak, D., C. Georgopoulos, M. Zylicz 1993. Isolation and characterization of ClpX, a new ATP-dependent specificity component of the Clp protease of Escherichia coli. J.Biol.Chem. 268:22609-22617
- Yoo, S.J., J.H. Seol, M.S. Kang, D.B. Ha, C.H. Chung 1994. clpX encoding an alternative ATP-binding subunit of protease Ti (Clp) can be expressed independently from clpP in Escherichia coli. Biochem.Biophys.Res.Commun. 203:798-804
- Levchenko, I., L. Luo, T.A. Baker 1995. Disassembly of the Mu transposase tetramer by the ClpX chaperone. Genes Dev. 9:2399-2408
- Frank, E.G., D.G. Ennis, M. Gonzalez, A.S. Levine, R. Woodgate 1996. Regulation of SOS mutagenesis by proteolysis. Proc.Natl.Acad.Sci.USA 93:10291-10296
- Bohn, C., E. Binet, P. Bouloc 2002. Screening for stabilization of proteins with a trans-translation signature in Escherichia coli selects for inactivation of the ClpXP protease. Molecular Genetics & Genomics: MGG 266:827-831