Site lpxL
- Name: lpxL
- Type: Gene
- Synonyms
b1054 MG1655 locus tag htrB original description waaM - Mnemonic: lipid A eXpression
- Left End Point: 24.03
- Right End Point: 24.05
- Products:
lauroyl transferase of lipid A biosynthesis KDO2-lipid IVA lauroyl-ACP acyltransferase - Direction: <
- Properties:
Property Comment encodes membrane protein NULL affects cell division/growth NULL - Priority: 0
- 1 Alleles of This Gene
lpxL10(ts)::mini-Tn10 - External Database Links:
Host Site Page Links EcoGene.org EG10464 EcoliWiki lpxL - Comment:
- high temperature survival. late functioning acyltransferase of lipid A biosynthesis. (required for rapid growth at 33C)
- References:
- Karow, M., O. Fayet, A. Cegielska, T. Ziegelhoffer, C. Georgopoulos 1991. Isolation and characterization of the Escherichia coli htrB gene, whose product is essential for bacterial viability above 33 degrees C in rich media. J.Bacteriol. 173:741-750
- Karow, M, S Raina, C Georgopoulos, O Fayet 1991. Complex phenotypes of null mutations in the htr genes, whose products are essential for Escherichia coli growth at elevated temperatures Res. Microbiol. 142(2-3):289-294.
- Karow, M., C. Georgopoulos 1991. Sequencing, mutational analysis, and transcriptional regulation of the Escherichia coli htrB gene. Mol.Microbiol. 5:2285-2292
- Clementz, T., J.J. Bednarski, C.R. Raetz 1996. Function of the htrB high temperature requirement gene of Escherichia coli in the acylation of lipid A: HtrB catalyzed incorporation of laurate. J.Biol.Chem. 271:12095-12102
- Clementz, T., Z. Zhou, C.R.H. Raetz 1997. Function of the Escherichia coli msbB gene, a multicopy suppressor of htrB knockouts, in the acylation of LipidA acylation by MsbB follows laurate incorporation by HtrB. J.Biol.Chem. 272:10353-10360
- Carty, S.M., K.R. Sreekumar, C.R. Raetz 1999. Effect of cold shock on lipid A biosynthesis in Escherichia coli.Induction At 12 degrees C of an acyltransferase specific for palmitoleoyl-acyl carrier protein. J.Biol.Chem. 274:9677-9685
- Vorachek-Warren, M.K., S. Ramirez, R.J. Cotter, C.R. Raetz 2002. A triple mutant of Escherichia coli lacking secondary acyl chains on lipid A. J.Biol.Chem. 277:14194-14205