Site lpxM
- Name: lpxM
- Type: Gene
- Synonyms
b1855 MG1655 locus tag mlt Engel et al for membrane-bound lytic transglycosylase msbB - Mnemonic: lipid A eXpression
- Left End Point: 41.76
- Right End Point: 41.78
- Products:
KDO2-lauroyl-lipidIV_A myristoyl-ACP acyltransferase - Direction: <
- Priority: 0
- 3 Alleles of This Gene
lpxM11($\Omega$)::Cm lpxM780(del)::kan lpxM794-YFP(::cat) - External Database Links:
Host Site Page Links EcoGene.org EG10614 EcoliWiki lpxM - Comment:
- MsbB transfers myristate or laurate, activated on ACP, to Lipid IVA moiety of (KDO)2-(Lauroyl)-lipid IVA. In multicopy suppresses htrB- lack of acylation of lipid A.
- References:
- Karow, M, C Georgopoulos 1992. Isolation and characterization of the Escherichia coli msbB gene, a multicopy suppressor of null mutations in the high-temperature requirement gene htrB. J. Bacteriol. 174(3):702-10.
- Clementz, T., Z. Zhou, C.R.H. Raetz 1997. Function of the Escherichia coli msbB gene, a multicopy suppressor of htrB knockouts, in the acylation of LipidA acylation by MsbB follows laurate incorporation by HtrB. J.Biol.Chem. 272:10353-10360
- Vorachek-Warren, M.K., S. Ramirez, R.J. Cotter, C.R. Raetz 2002. A triple mutant of Escherichia coli lacking secondary acyl chains on lipid A. J.Biol.Chem. 277:14194-14205