Pay an invoice 
Site ruvC
- Name: ruvC
- Type: Gene
- Synonyms
b1863 MG1655 locus tag - Mnemonic: repair uv?
- Left End Point: 41.92
- Right End Point: 41.93
- Products:
RuvC endonuclease RuvC resolvase - Direction: <
- Properties:
Property Comment encodes endonuclease encodes endonuclease that resolves Holliday struture repair system gene NULL - Priority: 0
- 5 Alleles of This Gene
ruvC51 ruvC53 ruvC67::cat ruvC789(del)::kan ruvC791-YFP(::cat) - External Database Links:
Host Site Page Links NCBI/GenBank D10165 NCBI/GenBank X59551 EcoGene.org EG10925 EcoliWiki ruvC - Comment:
- unlike ruvAB, not regulated by SOS system. RecA catalyzes pairing and strand exchange to form intermedate structures acted upon by RuvC
- References:
- Sharples, G.J., F.E. Benson, G.T. Illing, R.G. Lloyd 1990. Molecular and functional analysis of the ruv region of Escherichia coli K-12 reveals three genes involved in DNA repair and recombination. Mol.Gen.Genet. 221:219-226
- Lloyd, R.G. 1991. Conjugational recombination in resolvase-deficient ruvC mutants of Escherichia coli K-12 depends on recG. J.Bacteriol. 173:5414-5418
- Connolly, B., C.A. Parsons, F.E. Benson, H.J. Dunderdale, G.J. Sharples, R.G. Lloyd, S.C. West 1991. Resolution of Holliday junctions in vitro requires the Escherichia coli ruvC gene product. Proc.Natl.Acad.Sci.USA 88:6063-6067
- Sharples, G.J., R.G. Lloyd 1991. Resolution of Holliday junctions in Escherichia coli: identification of the ruvC gene product as a 19-kilodalton protein. J.Bacteriol. 173:7711-7715
- Iwasaki, H., M. Takahagi, T. Shiba, A. Nakata, H. Shinagawa 1991. Escherichia coli RuvC protein is an endonuclease that resolves the Holliday structure. EMBO J. 10:4381-4389
- Takahagi, M., H. Iwasaki, A. Nakata, H. Shinagawa 1991. Molecular analysis of the Escherichia coli ruvC gene, which encodes a Holliday junction-specific endonuclease. J.Bacteriol. 173:5747-5753
- Taylor, A.F. 1992. Movement and resolution of Holliday junctions by enzymes from E. coli. Cell 69:1063-1065
- West, S.C., B. Connolly 1992. Biological roles of the Escherichia coli RuvA, RuvB and RuvC proteins revealed. Mol.Microbiol. 6:2755-2759
- Sharples, G.J., R.G. Lloyd 1993. An E. coli RuvC mutant defective in cleavage of synthetic Holliday junctions. Nucleic Acids Res. 21:3359-3364
- West, S.C., I.R. Tsaneva, K. Hiom, F.E. Benson 1993. Late steps in genetic recombination: branch migration and Holliday junction resolution by RuvA, RuvB, and RuvC proteins. Cold Spr.Harb.Symp.Quant.Biol. 58:525-531
- Asai, T., S. Sommer, A. Bailone, T. Kogoma 1993. Homologous recombination-dependent initiation of DNA replication from DNA damage-inducible origins in Escherichia coli. EMBO J. 12:3287-3295
- Kowalczykowski, S.C., D.A. Dixon, A.K. Eggleston, S.D. Lauder, W.M. Rehrauer 1994. Biochemistry of homologous recombination in Escherichia coli. Microbiol.Rev. 58:401-465
- Dunderdale, H.J., G.J. Sharples, R.G. Lloyd, S.C. West 1994. Cloning, overexpression, purification and characterization of the Escherichia coli RuvC Holliday junction resolvase. J.Biol.Chem. 269:5187-5194
- Benson, F.E., S.C. West 1994. Substrate specificity of the Escherichia coli RuvC protein. Resolution of three- and four-stranded recombination intermediates. J.Biol.Chem. 269:5195-5201
- West, S.C. 1996. The RuvABC proteins and Holliday junction processing in Escherichia coli. J.Bacteriol. 178:1237-1241
- Bennett, R.J., S.C. West 1996. Resolution of Holliday junctions in genetic recombination: RuvC protein nicks DNA at the point of strand exchange. Proc.Natl.Acad.Sci.USA 93:12217-12222
- Zahradka, K., D. Zahradka, M. Petranovic 2001. Loss of lambda prophage recombinogenicity in UV-irradiated Escherichia coli: the role of host genes ruvA, ruvB, ruvC, and recG. Res.Microbiol. 152:873-881