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Site mfd
- Name: mfd
- Type: Gene
- Synonyms
b1114 MG1655 locus tag - Mnemonic: mutation frequency decline
- Left End Point: 25.21
- Right End Point: 25.29
- Products:
transcription-repair coupling factor - Direction: >
- Priority: 0
- 3 Alleles of This Gene
mfd-1 mfd-739(del)::kan mfd-791-YFP(::cat) - External Database Links:
Host Site Page Links EcoGene.org EG11619 EcoliWiki mfd - Comment:
- protein couples transcription to excision repair by binding to(displacing stalled)RNAP &to UvrA(recruiting repair enz.)Key in transcription repair coupling (e.g.,pref.repair of transcr.strand of tRNA)
- References:
- Selby, C.P., E.M. Witkin, A. Sancar 1991. Escherichia coli mfd mutant deficient in "mutation frequency decline" lacks strand-specific repair: in vitro complementation with purified coupling factor. Proc.Natl.Acad.Sci.USA 88:11574-11578
- Oller, A.R., I.J. Fijalkowska, R.L. Dunn, R.M. Schaaper 1992. Transcription-repair coupling determines the strandedness of ultraviolet mutagenesis in Escherichia coli. Proc.Natl.Acad.Sci.USA 89:11036-11040
- Selby, C.P., A. Sancar 1993. Transcription-repair coupling and mutation frequency decline. J.Bacteriol. 175:7509-7514
- Selby, C.P., A. Sancar 1993. Molecular mechanism of transcription-repair coupling. Science 260:53-58
- Selby, C.P., A. Sancar 1994. Mechanisms of transcription-repair coupling and mutation frequency decline. Microbiol.Rev. 58:317-329
- Selby, C.P., A. Sancar 1995. Structure and function of transcription-repair coupling factor. II. Catalytic properties. J.Biol.Chem. 270:4890-4895
- Selby, C.P., A. Sancar 1995. Structure and function of transcription-repair coupling factor. I. Structural domains and binding properties. J.Biol.Chem. 270:4882-4889