Site lptD
- Name: lptD
- Type: Gene
- Synonyms
b0054 MG1655 locus tag imp previous use as increased membr.permeabil. ostA Aono et al for organic solvent tolerant - Mnemonic: LPS transport
- Left End Point: 1.18
- Right End Point: 1.23
- Products:
component of outer membrane targeting/ushering system LptDE (formerly Imp-RlpB) complex - Direction: <
- Properties:
Property Comment essential gene NULL encodes membrane protein forms high MW complex in outer membrane - Priority: 0
- 3 Alleles of This Gene
lptD4213 lptD4213 lptD4213 - External Database Links:
Host Site Page Links EcoGene.org EG11569 EcoliWiki lptD - Comment:
- component of LptDE protein complex in inner leaflet of OM, receives and/or flips LPS from periplasm over OM.
- References:
- Sampson, B.A., R. Misra, S.A. Benson 1989. Identification and characterization of a new gene of Escherichia coli K-12 involved in outer membrane permeability. Genetics 122:491-501
- Aono, R., T. Negishi, H. Nakajima 1994. Cloning of organic solvent tolerance gene ostA that determines n-hexane tolerance level in Escherichia coli. Appl.Environ.Microbiol. 60:4624-4626
- Braun, M., T.J. Silhavy 2002. Imp/OstA is required for cell envelope biogenesis in Escherichia coli. Mol.Microbiol. 45:1289-1302
- Wu, T., J.C. Malinverni, N. Ruiz, S. Kim, T.J. Silhavy, D. Kahne 2005. Identification of a multicomponent complex required for outer membrane biogenesis in Escherichia coli. Cell 121:235-245
- Ruiz, N., B. Falcone, D. Kahne, T.J. Silhavy 2005. Chemical conditionality: a genetic strategy to probe organelle assembly.[comment]. Cell 121:307-317
- Ruiz, N., T. Wu, D. Kahne, T.J. Silhavy 2006. Probing the barrier function of the outer membrane with chemical conditionality.[see comment]. ACS Chem Biol 1:385-395
- Wu, T., A.C. McCandish, L.S. Gronenberg, S.S. Chng, T.J. Silhavy, D. Kahne 2006. Identification of a protein complex that assembles lipopolysaccharide in the outer membrane of Escherichia coli. Proc.Natl.Acad.Sci.USA 103:11754-11759