Site pncA
- Name: pncA
- Type: Gene
- Synonyms
b1768 MG1655 locus tag nam ydjB Blattner sequence and Rudd EcoGene - Mnemonic: Pyridine nucleotide cycle
- Left End Point: 39.88
- Right End Point: 39.89
- Products:
nicotinamide deamidase nicotinamidase and pyrazinamidase PZAase and nicotinamidase - Direction: >
- Priority: 1
- 4 Alleles of This Gene
pncA1 pncA20 pncA766(del)::kan pncA791-YFP(::cat) - External Database Links:
Host Site Page Links EcoGene.org EG11135 EcoliWiki pncA - Comment:
- Selectable phenotype. Loss: 6-aminonicotinamide resistance. Increase ("pncH"): use of nicotinamide as nitrogen source.
- References:
- Pardee, A.B., E.J. Benz, D.A. St. Peter, J.N. Krieger, M. Meuth, H.W. Triesmann 1971. Hyperproduction and purification of nicotinamide deamidase, a microconstitutive enzyme of Escherichia coli. J.Biol.Chem. 246:6792-6796
- Lemmon, R.D., J.J. Rowe, G. Tritz 1980. Isolation and characterization of mutants of Escherichia coli defective in pyridine nucleotide cycle enzymes. Curr.Microbiol. 4:31-35
- Frothingham, R., O.C.W.A. Meeker, E.A. Talbot, J.W. George, K.N. Kreuzer 1996. Identification, cloning, and expression of the Escherichia coli pyrazinamidase and nicotinamidase gene, pncA. Antimicrob.Agents Chemother. 40:1426-1431