Site nfsA
- Name: nfsA
- Type: Gene
- Synonyms
b0851 MG1655 locus tag mdaA Chatterjee and Sternberg - Mnemonic: Nitrofurazone sensitivity
- Left End Point: 19.19
- Right End Point: 19.21
- Products:
nitrofuran reductase I activity B nitroreductase, oxygen-insensitive - Direction: >
- Properties:
Property Comment member of SoxRS regulon - Priority: 1
- 2 Alleles of This Gene
nfsA1 nfsA752(del)::kan - External Database Links:
Host Site Page Links EcoGene.org EG11261 EcoliWiki nfsA - Comment:
- Selectable phenotype. Nitrofurazone resistance. Regulated by SoxS. ybjC-nfsA operon, paraquat-inducible.
- References:
- McCalla, D.R., C. Kaiser, M.H.L. Green 1978. Genetics of nitrofurazone resistance in Escherichia coli. J.Bacteriol. 133:10-16
- Breeze, A.S., E.E. Obaseiki-Ebor 1983. Mutations in nitrofurantoin and nitrofurazone resistance in Escherichia coli K-12. J.Gen.Microbiol. 129:99-103
- Chatterjee, P.K., N.L. Sternberg 1995. A general genetic approach in Escherichia coli for determining the mechanisms of action of tumoricidal agents: application to DMP 840, a tumoricidal agent. Proc.Natl.Acad.Sci.USA 92:8950-8954
- Zenno, S., H. Koike, A.N. Kumar, R. Jayaraman, M. Tanokura, K. Saigo 1996. Biochemical characterization of NfsA, the Escherichia coli major nitroreductase exhibiting a high amino acid sequence homology to Frp, a Vibrio harveyi flavin oxidoreductase. J.
- Zenno, S., T. Kobori, M. Tanokura, K. Saigo 1998. Conversion of NfsA, the major Escherichia coli nitroreductase, to a flavin reductase with an activity similar to that of Frp, a flavin reductase in Vibrio harveyi, by a single amino acid substitution. J
- Paterson, E.S., S.E. Boucher, I.B. Lambert 2002. Regulation of the nfsA Gene in Escherichia coli by SoxS. J.Bacteriol. 184:51-58