Site iscS
- Name: iscS
- Type: Gene
- Synonyms
b2530 Blattner seq. b2530 MG1655 locus tag csdB yfhO Rudd phys.map - Mnemonic: iron sulfur cluster
- Left End Point: 57.30
- Right End Point: 57.33
- Products:
NifS-like protein catalyzing formation of S and alanine from cysteine cysteine desulfurase sulfurtransferase in tRNA 4-thiouridine synthesis (also req. for 2-thiouridine syn. - Direction: <
- Priority: 0
- 2 Alleles of This Gene
iscS776(del)::kan iscS791-YFP(::cat) - External Database Links:
Host Site Page Links EcoGene.org EG12677 EcoliWiki iscS - Comment:
- References:
- Flint, D.H. 1996. Escherichia coli contains a protein that is homologous in function and N-terminal sequence to the protein encoded by the nifS gene of Azotobacter vinelandii and that can participate in the synthesis of the Fe-S cluster of dihydroxy-ac
- Mihara, H., M. Maeda, T. Fujii, T. Kurihara, Y. Hata, N. Esaki 1999. A nifS-like gene, csdB, encodes an Escherichia coli counterpart of mammalian selenocysteine lyase. J.Biol.Chem. 274:14768-14772
- Kambampati, R., C.T. Lauhon 1999. IscS is a sulfurtransferase for the in vitro biosynthesis of 4-thiouridine in Escherichia coli tRNA. Biochemistry 38:16561-16568
- Schwartz, C.J., O. Djaman, J.A. Imlay, P. Kiley 2000. The cysteine desulfurase, IscS, has a major role in in vivo Fe-S cluster formation in Escherichia coli. Proc.Natl.Acad.Sci.USA 97:9009-9014
- Kambampati, R., C.T. Lauhon 2003. MnmA and IscS are required for in vitro 2-thiouridine biosynthesis in Escherichia coli. Biochemistry 42:1109-1117