Site gshA
- Name: gshA
- Type: Gene
- Synonyms
b2688 MG1655 locus tag - Mnemonic: glutathione
- Left End Point: 60.63
- Right End Point: 60.67
- Products:
gamma-glutamyl-cysteine synthetase glutamate-cysteine ligase - Direction: <
- Priority: 1
- 5 Alleles of This Gene
gshA1 gshA2 gshA20::Tn10kan gshA769(del)::kan gshA791-YFP(::cat) - External Database Links:
Host Site Page Links EcoGene.org EG10418 EcoliWiki gshA - Comment:
- Selectable phenotype. Loss, in methylglyoxal-resistant strain: indicator plate. "First" step (of 2) in glutathione biosynthesis
- References:
- Murata, K., K. Tani, J.-I. Kato, I. Chibata 1981. Isolation of Escherichia coli B mutant deficient in glutathione biosynthesis. Agric.Biol.Chem. 45:2131-2132
- Haller, B.L., J.A. Fuchs 1984. Mapping of trxB, a mutation responsible for reduced thioredoxin reductase activity. J.Bacteriol. 159:1060-1062
- Greenberg, J., B. Demple 1986. Glutathione in Escherichia coli is dispensable for resistance to H2O2 and gamma radiation. J.Bacteriol. 168:1026-1029
- Watanabe, K., Y. Yamano, K. Murata, A. Kimura 1986. The nucleotide sequence of the gene for gamma-glutamylcysteine synthetase of Escherichia coli. Nucleic Acids Res. 14:4393-4400
- McLaggan, D., T.M. Logan, D.G. Lynn, W. Epstein 1990. Involvement of gamma-glutamyl peptides in osmoadaptation of Escherichia coli. J.Bacteriol. 172:3631-3636
- Gardner, P.R., I. Fridovich 1993. Effect of glutathione on aconitase in Escherichia coli. Arch.Biochem. 301:98-102