Site fnr
- Name: fnr
- Type: Gene
- Synonyms
b1334 MG1655 locus tag frdB nirA nirR ossA mutant allele - Mnemonic: fumarate-nitrate-reductase
- Left End Point: 30.11
- Right End Point: 30.13
- Products:
FNR, regulator of anaerobic respiratory genes - Direction: <
- Properties:
Property Comment regulatory gene for nitrite and nitrate reductases, hydrogenase, and fumarate reductase - Priority: 1
- 4 Alleles of This Gene
fnr-1 fnr-25 fnr-267(del) fnr-771(del)::kan - External Database Links:
Host Site Page Links EcoGene.org EG10325 EcoliWiki fnr - Comment:
- regulatory gene for nitrite and nitrate reductases, hydrogenase, and fumarate reductase. Iron-dependent, DNA-binding protein; activates transcr. of many anaerobically regulated genes.
- References:
- Shaw, D.J., J.R. Guest 1981. Molecular cloning of the fnr gene of Escherichia coli K-12. Mol.Gen.Genet. 181:95-100
- Shaw, D.J., J.R. Guest 1982. Amplification and product identification of the fnr gene of Escherichia coli. J.Gen.Microbiol. 128:2221-2228
- Stewart, V.J. 1982. Requirement of Fnr and NarL functions for nitrate reductase expression in Escherichia coli K-12. J.Bacteriol. 151:1320-1325
- Shaw, D.J., J.R. Guest 1982. Nucleotide sequence of the fnr gene and primary structure of the Fnr region of Escherichia coli. Nucleic Acids Res. 10:6119-6130
- Melville, S.B., R.P. Gunsalus 1990. Mutations in fnr that alter anaerobic regulation of electron transport-associated genes in Escherichia coli. J.Biol.Chem. 265:18733-18736
- Spiro, S., J.R. Guest 1990. FNR and its role in oxygen-regulated gene expression in Escherichia coli. FEMS Microbiol.Rev. 6:399-428
- Ramseier, T.M., S.Y. Chien, M.H. Saier 1996. Cooperative interaction between Cra and Fnr in the regulation of the cydAB operon of Escherichia coli. Curr.Microbiol. 33:270-274
- Saroja, G.N., J. Gowrishankar 1996. Roles of SpoT and FNR in NH4+ assimilation and osmoregulation in GOGAT (glutamate synthase)-deficient mutants of Escherichia coli. J.Bacteriol. 178:4105-4114