Site cueO
- Name: cueO
- Type: Gene
- Synonyms
b0123 MG1655 locus tag yacK - Mnemonic: Cu efflux regulator
- Left End Point: 2.95
- Right End Point: 2.99
- Products:
multicopper oxidase - Direction: >
- Priority: 0
- 3 Alleles of This Gene
cueO6(del)::FLK2(lacZ,kan) cueO741(del)::kan cueO791-YFP(::cat) - External Database Links:
Host Site Page Links EcoGene.org EG12318 EcoliWiki cueO - Comment:
- Regulated by copper-responsive CueR activator. Phenoloxidase activity. May lead to Cu resistance by oxidizing the catechol iron siderophore enterobactin: catecholates potentially reduce Cu++ to Cu+
- References:
- Outten, F.W., D.L. Huffman, J.A. Hale, T.V. O'Halloran 2001. The independent cue and cus systems confer copper tolerance during aerobic and anaerobic growth in Escherichia coli. J.Biol.Chem. 276:30670-30677
- Roberts, S.A., A. Weichsel, G. Grass, K. Thakali, J.T. Hazzard, G. Tollin, C. Rensing, W.R. Montfort 2002. Crystal structure and electron transfer kinetics of CueO, a multicopper oxidase required for copper homeostasis in Escherichia coli. Proc.Natl.Ac
- Grass, G., K. Thakali, P.E. Klebba, D. Thieme, A. Muller, G.F. Wildner, C. Rensing 2004. Linkage between catecholate siderophores and the multicopper oxidase CueO in Escherichia coli. J.Bacteriol. 186:5826-5833