Site tonB
- Name: tonB
- Type: Gene
- Synonyms
b1252 MG1655 locus tag exbA T1rec - Mnemonic: T-one (T1 phage)
- Left End Point: 28.22
- Right End Point: 28.23
- Products:
TonB-ExbB-ExbD cytoplasmic membrane-anchored complex component - Direction: >
- Properties:
Property Comment transport gene TonB-ExbB-ExbD complex couples action of OM transporters FhuA and BtuB across cytopl.memb., transfers energy to open channels in OMP receptors - Priority: 1
- 6 Alleles of This Gene
tonB50 tonB51 tonB52 tonB54 tonB56 tonB760(del)::kan - External Database Links:
Host Site Page Links NCBI/GenBank K00431 EcoGene.org EG11012 EcoliWiki tonB - Comment:
- uptake of chelated iron and cyanobalamin; sensitivity to phages T1, Phi80 and colicins. Sel.phen. Loss: phage T1, phage T5, phage $\chi80, colicin M, albomycin res.; phage T1, phage $\chi80,col res.
- References:
- Signer, E.R. 1966. Interaction of prophages at the att_80 site with the chromosome of Escherichia coli. J.Mol.Biol. 15:243-255
- Gratia, J. 1966. Studies on defective lysogeny due to chromosomal deletion in Escherichia coli. Biken J. 9:77-87
- Gottesman, S., J.R. Beckwith 1969. Directed transposition of the arabinose operon: a technique for the isolation of special transducing bacteriophages for any Escherichia coli gene. J.Mol.Biol. 44:117-127
- Bassford, P.J., C. Bradbeer, R.J. Kadner, C.A. Schnaitman 1976. Transport of vitamin B12 in tonB mutants of Escherichia coli. J.Bacteriol. 128:242-247
- Postle, K., W.S. Reznikoff 1979. Identification of the Escherichia coli tonB gene product in minicells containing tonB hybrid plasmids. J.Mol.Biol. 131:619-636
- Braun, V., J. Frenz, K. Hantke, H. Schaller 1980. Penetration of colicin M into cells of Escherichia coli. J.Bacteriol. 142:162-168
- Postle, K., R.F. Good 1983. DNA sequence of the Escherichia coli tonB gene. Proc.Natl.Acad.Sci.USA 80:5235-5239
- Postle, K., R.F. Good 1985. A bidirectional rho-independent transcription terminator between the E. coli tonB gene and an opposing gene. Cell 41:577-585
- Fischer, E., K. Gunter, V. Braun 1989. Involvement of ExbB and TonB in transport across the outer membrane of Escherichia coli: phenotypic complementation of exb mutants by overexpressed tonB and physical stabilization of TonB by ExbB. J.Bacteriol. 171
- Traub, I., S. Gaisser, V. Braun 1993. Activity domains of the TonB protein. Mol.Microbiol. 8:409-423
- Braun, V., C. Herrmann 1993. Evolutionary relationship of uptake systems for biopolymers in Escherichia coli: cross-complementation between the TonB-ExbB-ExbD and the TolA-TolQ-TolR proteins. Mol.Microbiol. 8:261-268
- Karlsson, M., K. Hannavy, C.F. Higgins 1993. ExbB acts as a chaperone-like protein to stabilize TonB in the cytoplasm. Mol.Microbiol. 8:389-396
- Karlsson, M., K. Hannavy, C.F. Higgins 1993. A sequence-specific function for the N-terminal signal-like sequence of the TonB protein. Mol.Microbiol. 8:379-388
- Killmann, H., V. Braun 1994. Energy-dependent receptor activities of Escherichia coli K-12: mutated TonB proteins alter FhuA receptor activities to phages T5, T1, phi80 and to colicin M. FEMS Microbiol.Lett. 119:71-76
- Traub, I., V. Braun 1994. Energy-coupled colicin transport through the outer membrane of Escherichia coli K-12: mutated TonB proteins alter receptor activities and colicin uptake. FEMS Microbiol.Lett. 119:65-70
- Pogliano, J.A., J.R. Beckwith 1994. SecD and SecF facilitate protein export in Escherichia coli. EMBO J. 13:554-561
- Kadner, R.J., K. Heller 1995. Mutual inhibition of cobalamin and siderophore uptake systems suggests their competition for TonB function. J.Bacteriol. 177:4829-4835
- Neilands, J.B. 1995. Siderophores: structure and function of microbial iron transport compounds. J.Biol.Chem. 270:26723-26726
- Letain, T.E., K. Postle 1997. TonB protein appears to transduce energy by shuttling between the cytoplasmic membrane and the outer membrane in Escherichia coli. Mol.Microbiol. 24:271-283
- Nagata, Y., K. Mashimo, M. Kawata, K. Yamamoto 2002. The roles of Klenow processing and flap processing activities of DNA polymerase I in chromosome instability in Escherichia coli K12 strains. Genetics 160:13-23