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Site cheA
- Name: cheA
- Type: Gene
- Synonyms
b1888 MG1655 locus tag - Mnemonic: Chemotaxis
- Left End Point: 42.49
- Right End Point: 42.54
- Products:
autophosphorylating histidine kinase in chemotaxis signal transduction methyl-accepting chemotaxis protein CheAL CheAS - Direction: <
- Properties:
Property Comment flagellar regulon member chemotactic signal transduction chemotact.signal transd.gene NULL alternate translat'n init.site result in CheAL and CheAS proteins - Priority: 1
- 1 Alleles of This Gene
cheA741(del)::kan - External Database Links:
Host Site Page Links NCBI/GenBank M34669 EcoGene.org EG10146 EcoliWiki cheA - Comment:
- Chemotactic response. Autophosphorylation produces clockwise signal, inhibition of CheA (by Tsr, for example) produces CCW signal.
- References:
- Silverman, M., M. Simon 1973. Genetic analysis of flagellar mutants in Escherichia coli. J.Bacteriol. 113:105-113
- Smith, R.A., J.S. Parkinson 1980. Overlapping genes at the cheA locus of Escherichia coli. Proc.Natl.Acad.Sci.USA 77:5370-5374
- Slocum, M.K., J.S. Parkinson 1983. Genetics of methyl-accepting chemotaxis proteins in Escherichia coli: organization of the tar region. J.Bacteriol. 155:565-577
- Kofoid, E.C., J.S. Parkinson 1991. Tandem translation starts in the cheA locus of Escherichia coli. J.Bacteriol. 173:2116-2119
- Tawa, P., R.C. Stewart 1994. Mutational activation of CheA, the protein kinase in the chemotaxis system of Escherichia coli. J.Bacteriol. 176:4210-4218
- Rowsell, E.H., J.M. Smith, A. Wolfe, B.L. Taylor 1995. CheA, CheW, and CheY are required for chemotaxis to oxygen and sugars of the phosphotransferase system in Escherichia coli. J.Bacteriol. 177:6011-0
- Lux, R., K. Jahreis, K. Bettenbrock, J.S. Parkinson, J.W. Lengeler 1995. Coupling the phosphotransferase system and the methyl-accepting chemotaxis protein-dependent chemotaxis signaling pathways of Escherichia coli. Proc.Natl.Acad.Sci.USA 92:11583-115
- Sanatinia, H., E.C. Kofoid, T.B. Morrison, J.S. Parkinson 1995. The smaller of two overlapping cheA gene products is not essential for chemotaxis in Escherichia coli. J.Bacteriol. 177:2713-2720
- Zhou, H, DF Lowry, RV Swanson, MI Simon, FW Dahlquist 1995. NMR studies of the phosphotransfer domain of the histidine kinase CheA from Escherichia coli: assignments, secondary structure, general fold, and backbone dynamics. Biochemistry 34(42):13858-70.
- Wang, H., P. Matsumura 1996. Characterization of the CheAS/CheZ complex: a specific interaction resulting in enhanced dephosphorylating activity on CheY-phosphate. Mol.Microbiol. 19:695-703
- Ames, P., Y.A. Yu, J.S. Parkinson 1996. Methylation segments are not required for chemotactic signalling by cytoplasmic fragments of Tsr, the methyl-accepting serine chemoreceptor of Escherichia coli. Mol.Microbiol. 19:737-746