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Site hns
- Name: hns
- Type: Gene
- Synonyms
b1237 MG1655 locus tag bglY pre-'90 map cur drc drdX drs fimG irk msyA Ueguchi and Ito osmZ pilG topX virR - Mnemonic: histone (HNS)-like protein
- Left End Point: 27.84
- Right End Point: 27.85
- Products:
H-NS (H1a) DNA-binding protein, histone-like H1 histone-like protein - Direction: <
- Properties:
Property Comment encodes NA-binding protein NULL - Priority: 1
- 4 Alleles of This Gene
hns-1 hns-206 hns-746(del)::kan hns-846(del)::FRT - External Database Links:
Host Site Page Links EcoGene.org EG10457 EcoliWiki hns - Comment:
- DNA supercoiling; expression of genes subject to osmotic regulation. HNS nucleoid-associated protein. Histone-like protein HLP-II (HU,BH2,HD,NS); earlier incorrectly located at 6.1
- References:
- Diderichsen, B. 1980. cur-1, a mutation affecting the phenotype of sup$^+$ strains of Escherichia coli. Mol.Gen.Genet. 180:425-428
- Laine, B., P. Sautiere, A. Spassky, S. Rimsky 1984. A DNA-binding protein from E. coli isolation, characterization and its relationship with proteins H1 and B1. Biochem.Biophys.Res.Commun. 119:1147-1153
- Cunningham, P.R., D.P. Clark 1986. The use of suicide substrates to select mutants of Escherichia coli lacking enzymes of alcohol fermentation. Mol.Gen.Genet. 205:487-493
- Spears, P.A., D. Schauer, P.E. Orndorff 1986. Metastable regulation of type 1 piliation in Escherichia coli and isolation and characterization of a phenotypically stable mutant. J.Bacteriol. 168:179-185
- Pon, C.L., R.A. Calogero, C.O. Gualerzi 1988. Identification, cloning, nucleotide sequence and chromosomal map location of hns, the structural gene of Escherichia coli DNA-binding protein H-NS. Mol.Gen.Genet. 212:199-202
- Higgins, C.F., C.J. Dorman, D.A. Stirling, L. Waddell, I.R. Booth, G. May, E. Bremer 1988. A physiological role for DNA supercoiling in the osmotic regulation of gene expression in S. typhimurium and E. coli. Cell 52:569-584
- Lejeune, P., P. Bertin, C. Walon, K. Willemot, C. Colson, A. Danchin 1989. A locus involved in kanamycin, chloramphenicol and L-serine resistance is located in the bglY-galU region of the Escherichia coli K12 chromosome. Mol.Gen.Genet. 218:361-363
- Lejeune, P., A. Danchin 1990. Mutations in the bglY gene increase the frequency of spontaneous deletions in Escherichia coli K12. Proc.Natl.Acad.Sci.USA 87:360-363
- May, G., P. Dersch, M. Haardt, A. Middendorf, E. Bremer 1990. The osmZ (bglY) gene encodes the DNA-binding protein H-NS (H1a), a component of the Escherichia coli K12 nucleoid. Mol.Gen.Genet. 224:81-90
- Leonardo, MR, DP Clark 1991. Locations of genes in the nar-adhE region of the Escherichia coli K-12 chromosome. J. Bacteriol. 173(5):1574-5.
- Yamada, H., T. Yoshida, K. Tanaka, C. Sasakawa, T. Mizuno 1991. Molecular analysis of the Escherichia coli hns gene encoding a DNA-binding protein, which preferentially recognizes curved DNA sequences. Mol.Gen.Genet. 230:332-326
- La Teana, A., A. Brandi, M. Falconi, R. Spurio, C.L. Pon, C.O. Gualerzi 1991. Identification of a cold shock transcriptional enhancer of the Escherichia coli gene encoding nucleoid protein H-NS. Proc.Natl.Acad.Sci.USA 88:10907-10911
- Spurio, R., M. Durrenberger, M. Falconi, A. La Teana, C.L. Pon, C.O. Gualerzi 1992. Lethal overproduction of the Escherichia coli nucleoid protein H-NS: ultramicroscopic and molecular autopsy. Mol.Gen.Genet. 231:201-211
- Barr, G.C., N.N. Bhriain, C.J. Dorman 1992. Identification of two new genetically active regions associated with the osmZ locus of Escherichia coli: role in regulation of proU expression and mutagenic effect of cya, the structural gene for adenylate cy
- Ueguchi, C., K. Ito 1992. Multicopy suppression: an approach to understanding intracellular functioning of the protein export system. J.Bacteriol. 174:1454-1461
- Shi, X., B.C. Waasdorp, G. Bennett 1993. Modulation of acid-induced amino acid decarboxylase gene expression by hns in Escherichia coli. J.Bacteriol. 175:1182-1186
- Bertin, P., E. Terao, E.H. Lee, P. Lejeune, C. Colson, A. Danchin, E. Collatz 1994. The H-NS protein is involved in the biogenesis of flagella in Escherichia coli. J.Bacteriol. 176:5537-5540
- Goosen, N., P. van de Putte 1995. The regulation of transcription initiation by integration host factor. Mol.Microbiol. 16:1-7
- Ueguchi, C., T. Suzuki, T. Yoshida, K. Tanaka, T. Mizuno 1996. Systematic mutational analysis revealing the functional domain organization of Escherichia coli nucleoid protein H-NS. J.Mol.Biol. 263:149-162
- Falconi, M., A. Brandi, A. La Teana, C.O. Gualerzi, C.L. Pon 1996. Antagonistic involvement of FIS and H-NS proteins in the transcriptional control of hns expression. Mol.Microbiol. 19:965-975
- Katayama, T., M. Takata, K. Sekimizu 1996. The nucleoid protein H-NS facilitates chromosome DNA replication in Escherichia coli dnaA mutants. J.Bacteriol. 178:5790-5792
- Rajkumari, K., S. Kusano, A. Ishihama, T. Mizuno, J. Gowrishankar 1996. Effects of H-NS and potassium glutamate on sigmaS- and sigma70-directed transcription in vitro from osmotically regulated P1 and P2 promoters of proU in Escherichia coli. J.Bacteri
- Williams, R.M., S. Rimsky 1997. Molecular aspects of the E.coli nucleoid protein, H-NS: a central controller of gene regulatory networks. FEMS Microbiol.Lett. 156:175-185
- Liu, X., T. Ferenci 2001. An analysis multifactorial influences on the transcriptional control ompF and ompC porin expression under nutrient limitation. Microbiology 147:2981-2989
- Landini, P., A.J. Zehnder 2002. The global regulatory hns gene negatively affects adhesion to solid surfaces by anaerobically grown Escherichia coli by modulating expression of flagellar genes and lipopolysaccharide production. J.Bacteriol. 184:1522-15