Site ampC
- Name: ampC
- Type: Gene
- Synonyms
ampA b4150 MG1655 locus tag pbpC - Mnemonic: Ampicillin
- Left End Point: 94.31
- Right End Point: 94.34
- Products:
beta-lactamase, Type C, and PBP C - Direction: <
- Priority: 1
- 4 Alleles of This Gene
ampC11 ampC12 ampC3 ampC777(del)::kan - External Database Links:
Host Site Page Links EcoGene.org EG10040 EcoliWiki ampC - Comment:
- penicillin resistance. Selectable Pheno. Increased expression: ampicillin resistance; Duplication: ampicillin resistance. Affects cell morphology, peptidoglycan synth./metab.
- References:
- Eriksson-Grennberg, K.G., H.G. Boman, J.A.T. Jansson, S. Thoren 1965. Resistance of Escherichia coli to penicillins. I. Genetic study of some ampicillin mutants. J.Bacteriol. 90:54-62
- Normark, S., T. Edlund, T. Grundstrom, S. Bergstrom, H. Wolf-Watz 1977. Escherichia coli K-12 mutants hyperproducing chromosomal beta-lactamase by gene repetitions. J.Bacteriol. 132:912-922
- Cole, S.T., J.R. Guest 1979. Production of a soluble form of fumarate reductase by multiple gene duplications in Escherichia coli K12. Eur.J.Biochem. 102:65-71
- Edlund, T., T. Grundstrom, S. Normark 1979. Isolation and characterization of DNA repetitions carrying the chromosomal B-lactamase gene of Escherichia coli K-12. Mol.Gen.Genet. 173:115-125
- Grundstrom, T., B. Jaurin, T. Edlund, S. Normark 1980. Physical mapping and expression of hybrid plasmids carrying chromosomal beta-lactamase genes of Escherichia coli K-12. J.Bacteriol. 143:1127-1134
- Jaurin, B., T. Grundstrom 1981. ampC cephalosporinase of Escherichia coli K-12 has a different evolutionary origin from that of beta-lactamase of the penicillinase type. Proc.Natl.Acad.Sci.USA 78:4897-4901
- Edlund, T., S. Normark 1981. Recombination between short DNA homologies causes tandem duplications. Nature 292:269-271
- Jaurin, B., T. Grundstrom, T. Edlund, S. Normark 1981. The E. coli beta-lactamase attenuator mediates growth rate-dependent regulation. Nature 290:221-225
- Grundstrom, T., B. Jaurin 1982. Overlap between ampC and frd operons on the Escherichia coli chromosome. Proc.Natl.Acad.Sci.USA 79:1111-1115
- Jaurin, B., T. Grundstrom, S. Normark 1982. Sequence elements determining ampC promoter strength in E. coli. EMBO J. 1:875-881
- Henderson, T.A., K.D. Young, S.A. Denome, P.K. Elf 1997. AmpC and AmpH, proteins related to the class C beta-lactamases, bind penicillin and contribute to the normal morphology of Escherichia coli. J.Bacteriol. 179:6112-6121