Site acrA
- Name: acrA
- Type: Gene
- Synonyms
b0463 MG1655 locus tag lir Mb mbl mtcA sipB suppr.incr.permeab.,Qi et al., allele of acrA?? - Mnemonic: Acridine
- Left End Point: 10.43
- Right End Point: 10.45
- Products:
AcrAB efflux pump - Direction: <
- Priority: 1
- 3 Alleles of This Gene
acrA1 acrA13 acrA748(del)::kan - External Database Links:
Host Site Page Links NCBI/GenBank U00734 EcoGene.org EG11703 EcoliWiki acrA - Comment:
- AcrAB efflux system plays major role in Mar multiple resistance (to Nal, Tet, Amp, etc.) acrA mutants are sensitive to methylene blue (50 ug/ml)
- References:
- Coleman, W.G., L. Leive 1979. Two mutations which affect the barrier function of the Escherichia coli K-12 outer membrane. J.Bacteriol. 139:899-910
- Henson, J.M., J.R. Walker 1982. Genetic analysis of acrA and lir mutations of Escherichia coli. J.Bacteriol. 152:1301-1302
- Qi, S.-Y., S. Sukopolvi, C.D. O'Connor 1991. Outer membrane permeability of Escherichia coli K12: isolation, cloning and mapping of suppressors of a defined antibiotic hypersensitive mutant. Mol.Gen.Genet. 229:421-427
- Ma, D., D.N. Cook, M. Alberti, N.G. Pon, H. Nikaido, J.E. Hearst 1993. Molecular cloning and characterization of acrA and acrE genes of Escherichia coli. J.Bacteriol. 175:6299-6313
- Ma, D., D.N. Cook, M. Alberti, N.G. Pon, H. Nikaido, J.E. Hearst 1995. Genes acrA and acrB encode a stress-induced efflux system of Escherichia coli. Mol.Microbiol. 16:45-55
- Okusu, H., D. Ma, H. Nikaido 1996. AcrAB efflux pump plays a major role in the antibiotic resistance phenotype of Escherichia coli multiple-antibiotic-resistance (Mar) mutants. J.Bacteriol. 178:306-308
- Fralick, J.A. 1996. Evidence that TolC is required for functioning of the Mar/AcrAB efflux pump of Escherichia coli. J.Bacteriol. 178:5803-5805
- White, D.G., J.D. Goldman, B. Demple, S.B. Levy 1997. Role of the acrAB locus in organic solvent tolerance mediated by expression of marA, soxS, or robA in Escherichia coli. J.Bacteriol. 179:6122-6126
- Rand, J.D., S.G. Danby, D.L. Greenway, R.R. England 2002. Increased expression of the multidrug efflux genes acrAB occurs during slow growth of Escherichia coli. FEMS Microbiol.Lett. 207:91-95