Site sodA
- Name: sodA
- Type: Gene
- Synonyms
b3908 MG1655 locus tag - Mnemonic: SOD, superoxide dismutase
- Left End Point: 88.34
- Right End Point: 88.36
- Products:
superoxide dismutase, Mn MnSOD - Direction: >
- Properties:
Property Comment member of soxRS regulon iron uptake regulon probably member of this regulon - Priority: 1
- 2 Alleles of This Gene
sodA25::MudIIPR13 sodA768(del)::kan - External Database Links:
Host Site Page Links NCBI/GenBank M20984 EcoGene.org EG10953 EcoliWiki sodA - Comment:
- Protects against metal stress.
- References:
- Touati, D. 1983. Cloning and mapping of the manganese superoxide dismutase gene (sodA) of Escherichia coli K-12. J.Bacteriol. 155:1078-1087
- Carlioz, A., D. Touati 1986. Isolation of superoxide dismutase mutants in Escherichia coli: is superoxide dismutase necessary for aerobic life?. EMBO J. 5:623-630
- Takeda, Y., H. Avila 1986. Structure and gene expression of the E. coli Mn-superoxide dismutase gene. Nucleic Acids Res. 14:4577-4589
- Privalle, C.T., I. Fridovich 1987. Induction of superoxide dismutase in Escherichia coli by heat shock. Proc.Natl.Acad.Sci.USA 84:2723-2726
- Niederhoffer, E.C., C.M. Naranjo, K.L. Bradley, J.A. Fee 1990. Control of Escherichia coli superoxide dismutase (sodA and sodB) genes by the ferric uptake regulation (fur) locus. J.Bacteriol. 172:1930-1938
- Fee, J.A. 1991. Regulation of sod genes in Escherichia coli: relevance to superoxide dismutase function. Mol.Microbiol. 5:2599-2610
- Tardat, B., D. Touati 1991. Two global regulators repress the anaerobic expression of MnSOD in Escherichia coli: Fur (ferric uptake regulation) and Arc (aerobic respiration control). Mol.Microbiol. 5:455-465
- Privalle, C.T., I. Fridovich 1992. Transcriptional and maturational effects of manganese and iron on the biosynthesis of manganese-superoxide dismutase in Escherichia coli. J.Biol.Chem. 267:9140-9145
- Compan, I., D. Touati 1993. Interaction of six global transcription regulators in expression of manganese superoxide dismutase in Escherichia coli K-12. J.Bacteriol. 175:1687-1696
- Benov, L., I. Fridovich 1995. A superoxide dismutase mimic protects sodA sodB Escherichia coli against aerobic heating and stationary-phase death. Arch.Biochem.Biophys. 322:291-294
- Benov, L., I. Fridovich 1998. Growth in iron-enriched medium partially compensates Escherichia coli for the lack of manganese and iron superoxide dismutase. J.Biol.Chem. 273:10313-10316
- Geslin, C., J. Llanos, D. Prieur, C. Jeanthon 2001. The manganese and iron superoxide dismutases protect Escherichia coli from heavy metal toxicity. Res.Microbiol. 152:901-905
- Bebien, M., G. Lagniel, J. Garin, D. Touati, A. Vermeglio, J. Labarre 2002. Involvement of superoxide dismutases in the response of Escherichia coli to selenium oxides. J.Bacteriol. 184:1556-1564