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Site uvrD
- Name: uvrD
- Type: Gene
- Synonyms
b3813 MG1655 locus tag dar-2 dda mutU pdeB rad recL srjC uvr502 uvrE - Mnemonic: Ultraviolet repair
- Left End Point: 86.13
- Right End Point: 86.17
- Products:
DNA-dependent ATPaseI-DNA helicase II DNA helicase II - Direction: >
- Properties:
Property Comment encodes helicase NULL encodes DNA-dependent ATPase NULL - Priority: 1
- 8 Alleles of This Gene
uvrD156 uvrD252 uvrD282::Tn5 uvrD291(del-ins,::tet) uvrD3 uvrD502 uvrD769(del)::kan uvrD794-YFP(::cat) - External Database Links:
Host Site Page Links NCBI/GenBank X00225 NCBI/GenBank D00069 NCBI/GenBank X04037 EcoGene.org EG11064 EcoliWiki uvrD - Comment:
- mutants show UV sensitivity and/or increased rates of spontaneous mutagenesis
- References:
- Oeda, K., T. Horiuchi, M. Sekiguchi 1981. Molecular cloning of the uvrD gene of Escherichia coli that controls ultraviolet sensitivity and spontaneous mutation frequency. Mol.Gen.Genet. 184:191-199
- Siegel, E. 1981. Complementation studies with the repair-deficient uvrD3, uvrE156, and recL152 mutations in Escherichia coli. Mol.Gen.Genet. 184:526-530
- Oeda, K., T. Horiuchi, M. Sekiguchi 1982. The uvrD gene of E. coli encodes a DNA-dependent ATPase. Nature 298:98-100
- Maples, V.F., S.R. Kushner 1982. DNA repair in Escherichia coli: identification of the uvrD gene product. Proc.Natl.Acad.Sci.USA 79:5616-5620
- Hickson, I.D., H.M. Arthur, D. Bramhill, P.T. Emmerson 1983. The E. coli uvrD gene product is DNA helicase II. Mol.Gen.Genet. 190:265-270
- Finch, P.W., P.T. Emmerson 1983. Nucleotide sequence of the regulatory region of the uvrD gene of Escherichia coli. Gene 25:317-323
- Easton, A.M., S.R. Kushner 1983. Transcription of the uvrD gene of Escherichia coli is controlled by the lexA repressor and by attenuation. Nucleic Acids Res. 11:8625-8640
- Arthur, H.M., P.B. Eastlake 1983. Transcriptional control of the uvrD gene of Escherichia coli. Gene 25:309-316
- Taucher-Scholz, G., H. Hoffmann-Berling 1983. Identification of the gene for DNA helicase II of Escherichia coli. Eur.J.Biochem. 137:573-580
- Kumura, K., M. Sekiguchi 1984. Identification of the uvrD gene product of Escherichia coli as DNA helicase II and its induction by DNA-damaging agents. J.Biol.Chem. 259:1560-1565
- Finch, P.W., P.T. Emmerson 1984. The nucleotide sequence of the uvrD gene of E. coli. Nucleic Acids Res. 12:5789-5799
- Yamamoto, Y., T. Ogawa, H. Shinagawa, T. Nakayama, H. Matsuo, H. Ogawa 1986. Determination of the initiation sites of transcription and translation of the uvrD gene of Escherichia coli. J.Biochem.(Tokyo) 99:1579-1590
- Aldea, M., V.F. Maples, S.R. Kushner 1988. Generation of a detailed physical and genetic map of the ilv-metE-udp region of the Escherichia coli chromosome. J.Mol.Biol. 200:427-438
- Washburn, B.K., S.R. Kushner 1991. Construction and analysis of deletions in the structural gene (uvrD) for DNA helicase II of Escherichia coli. J.Bacteriol. 173:2569-2575
- Daniels, D.L., G. Plunkett, V.D. Burland, F.R. Blattner 1992. Analysis of the Escherichia coli genome: DNA sequence of the region from 84.5 to 86.5 minutes. Science 257:771-778
- Washburn, B.K., S.R. Kushner 1993. Characterization of DNA helicase II from a uvrD252 mutant of Escherichia coli. J.Bacteriol. 175:341-350
- Mendonca, V.M., H.D. Klepin, S.W. Matson 1995. DNA helicases in recombination and repair: construction of a Delta uvrD Delta helD Delta recQ mutant deficient in recombination and repair. J.Bacteriol. 177:1326-1335
- Mendonca, V.M., S.W. Matson 1995. Genetic analysis of delta helD and delta uvrD mutations in combination with other genes in the RecF recombination pathway in Escherichia coli: suppression of a ruvB mutation by a uvrD deletion. Genetics 141:443-452
- Lovett, S.T., V.A. Sutera 1995. Suppression of recJ exonuclease mutants of Escherichia coli by alterations in DNA helicases II (uvrD) and IV (helD). Genetics 140:27-45
- Brosh, R.M., S.W. Matson 1995. Mutations in motif II of Escherichia coli DNA helicase II render the enzyme nonfunctional in both mismatch repair and excision repair with differential effects on the unwinding reaction. J.Bacteriol. 177:5612-5621
- Zhang, G., E. Deng, L.R. Baugh, C.M. Hamilton, V.F. Maples, S.R. Kushner 1997. Conserved motifs II to VI of DNA helicase II from Escherichia coli are all required for biological activity. J.Bacteriol. 179:7544-7550
- Hall, M.C., J.R. Jordan, S.W. Matson 1998. Evidence for a physical interaction between the Escherichia coli methyl-directed mismatch repair proteins MutL and UvrD. EMBO J. 17:1535-1541
- Zhang, G., E. Deng, L. Baugh, S.R. Kushner 1998. Identification and characterization of Escherichia coli DNA helicase II mutants that exhibit increased unwinding efficiency. J.Bacteriol. 180:377-387
- Petranovic, M., K. Zahradka, D. Zahradka, D. Petranovic, B. Nagy, E. Salaj-Smic 2001. Genetic evidence that the elevated levels of Escherichia coli helicase II antagonize recombinational DNA repair. Biochimie 83:1041-1047