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Site mutY
- Name: mutY
- Type: Gene
- Synonyms
b2961 MG1655 locus tag micA - Mnemonic: Mutator
- Left End Point: 66.84
- Right End Point: 66.87
- Products:
adenine glycosylase, G-A repair - Direction: >
- Priority: 1
- 3 Alleles of This Gene
mutY101::mini-Tn10 mutY736(del)::kan mutY795-YFP(::cat) - External Database Links:
Host Site Page Links EcoGene.org EG10627 EcoliWiki mutY - Comment:
- High rate of G.C--T.A transversions. Selectable phenotype. Streptomycin resistance; azaserine resistance; chemostat growth.
- References:
- Siegel, E., V. Bryson 1967. Mutator gene of Escherichia coli. J.Bacteriol. 94:38-47
- Helling, R.B. 1968. Selection of a mutant of Escherichia coli which has high mutation rates. J.Bacteriol. 96:975-980
- Cox, E.C., T. Gibson 1974. Selection for high mutation rates in chemostats. Genetics 77:169-184
- Nghiem, Y., M. Cabrera, C.G. Cupples, J.H. Miller 1988. The mutY gene: a mutator locus in Escherichia coli that generates G . C -> T . A transversions. Proc.Natl.Acad.Sci.USA 85:2709-2713
- Michaels, M.L., L. Pham, Y. Nghiem, C. Cruz, J.H. Miller 1990. MutY, an adenine glycosylase active on G-A mispairs, has homology to endonuclease III. Nucleic Acids Res. 18:3841-3845
- Tsai-Wu, J.J., J.P. Radicella, A.L. Lu 1991. Nucleotide sequence of the Escherichia coli micA gene required for A/G-specific mismatch repair: identity of micA and mutY. J.Bacteriol. 173:1902-1910
- Tsai-Wu, J.J., H.F. Liu, A.L. Lu 1992. Escherichia coli MutY protein has both N-glycosylase and apurinic/apyrimidinic endonuclease activities on A.C and A.G mispairs. Proc.Natl.Acad.Sci.USA 89:8779-8783
- Radicella, J.P., E.A. Clark, S. Chen, M.S. Fox 1993. Patch length of localized repair events: role of DNA polymerase I in mutY-dependent mismatch repair. J.Bacteriol. 175:7732-7736