Site marA
- Name: marA
- Type: Gene
- Synonyms
b1531 MG1655 locus tag cfxB? norB? soxQ - Mnemonic: multiple antibiotic resistance
- Left End Point: 34.87
- Right End Point: 34.88
- Products:
Mar transcriptional activator protein - Direction: >
- Properties:
Property Comment transcription factor gene transcriptional activator of mult.antibiotic promoters regulatory gene NULL - Priority: 1
- 1 Alleles of This Gene
marA752(del)::kan - External Database Links:
Host Site Page Links NCBI/GenBank M96235 EcoGene.org EG11434 EcoliWiki marA - Comment:
- Multiple antibiotic resistance; tetracycline.Expression induced by exposure to salicylate. High homology of MarA with SoxS
- References:
- George, A.M., S.B. Levy 1983. Gene in the major cotransduction gap of the Escherichia coli K-12 linkage map required for the expression of chromosomal resistance to tetracycline and other antibiotics. J.Bacteriol. 155:541-548
- Hirai, K., H. Aoyama, S. Suzue, T. Irikura, S. Iyobe, S. Mitsuhashi 1986. Isolation and characterization of norfloxacin-resistant mutants of Escherichia coli K-12. Antimicrob.Agents Chemother. 30:248-253
- Cohen, S.P., L.M. McMurry, S.B. Levy 1988. marA locus causes decreased expression of OmpF porin in multiple-antibiotic-resistant (Mar) mutants of Escherichia coli. J.Bacteriol. 170:5416-5422
- Hachler, H., S.P. Cohen, S.B. Levy 1991. marA, a regulated locus which controls expression of chromosomal multiple antibiotic resistance in Escherichia coli. J.Bacteriol. 173:5532-5538
- Greenberg, J., J.H. Chou, P.A. Monach, B. Demple 1991. Activation of oxidative stress genes by mutations at the soxZ/cfxB/marA locus of Escherichia coli. J.Bacteriol. 173:4433-4439
- Gambino, L., S.J. Gracheck, P.F. Miller 1993. Overexpression of the MarA positive regulator is sufficient to confer multiple antibiotic resistance in Escherichia coli. J.Bacteriol. 175:2888-2894
- Cohen, S.P., H. Hachler, S.B. Levy 1993. Genetic and functional analysis of the multiple antibiotic resistance (mar) locus in Escherichia coli. J.Bacteriol. 175:1484-1492
- Rosner, J.L., J.L. Slonczewski 1994. Dual regulation of inaA by the multiple antibiotic resistance (mar) and superoxide (soxRS) stress response systems of Escherichia coli. J.Bacteriol. 176:6262-6269
- Ariza, R.R., S.P. Cohen, N. Bachhawat, S.B. Levy, B. Demple 1994. Repressor mutations in the marRAB operon that activate oxidative stress genes and multiple antibiotic resistance in Escherichia coli. J.Bacteriol. 176:143-148
- Jair, K.W., R.G. Martin, J.L. Rosner, N. Fujita, A. Ishihama, R.E. Wolf 1995. Purification and regulatory properties of MarA protein, a transcriptional activator of Escherichia coli multiple antibiotic and superoxide resistance promoters. J.Bacteriol.
- Martin, R.G., K.W. Jair, R.E. Wolf, J.L. Rosner 1996. Autoactivation of the marRAB multiple antibiotic resistance operon by the MarA transcriptional activator in Escherichia coli. J.Bacteriol. 178:2216-2223
- Goldman, J.D., D.G. White, S.B. Levy 1996. Multiple antibiotic resistance (mar) locus protects Escherichia coli from rapid cell killing by fluoroquinolones. Antimicrob.Agents Chemother. 40:1266-1269
- Hachler, H., S.P. Cohen, S.B. Levy 1996. Untranslated sequence upstream of MarA in the multiple antibiotic resistance locus of Escherichia coli is related to the effector-binding domain of the XylS transcriptional activator. J.Mol.Evol. 42:409-413
- White, D.G., K. Maneewannakul, E. von Hofe, M. Zillman, W. Eisenberg, A.K. Field, S.B. Levy 1997. Inhibition of the multiple antibiotic resistance (mar) operon in Escherichia coli by antisense DNA analogs. Antimicrob.Agents Chemother. 41:2699-2704