Site uvrA
- Name: uvrA
- Type: Gene
- Synonyms
b4058 MG1655 locus tag dar - Mnemonic: Ultraviolet repair
- Left End Point: 92.01
- Right End Point: 92.07
- Products:
excision nuclease - Direction: <
- Properties:
Property Comment lexA regulon NULL SOS-related NULL ABC uvrA is one of few ABC proteins not transport related, see Linton and Higgins - Priority: 1
- 15 Alleles of This Gene
uvrA0 uvrA103 uvrA14 uvrA154 uvrA155 uvrA157 uvrA18 uvrA19 uvrA215::Mud(Ap,lac) uvrA277::Tn10 uvrA281 uvrA37 uvrA6 uvrA753(del)::kan uvrA791-YFP(::cat) - External Database Links:
Host Site Page Links NCBI/GenBank J01721 NCBI/GenBank M13495 NCBI/GenBank X01621 EcoGene.org EG11061 EcoliWiki uvrA - Comment:
- Cooper & Hanawalt 1972 PNAS USA 69:1156. Encodes an ATPase with the ABC family characteristics.
- References:
- Sancar, A., R.P. Wharton, S. Seltzer, B.M. Kacinski, N.D. Clarke, W.D. Rupp 1981. Identification of the uvrA gene product. J.Mol.Biol. 148:45-62
- Kenyon, C.J., G.C. Walker 1981. Expression of the E. coli uvrA gene is inducible. Nature 289:808-810
- Sancar, A., G.B. Sancar, W.D. Rupp, J.W. Little, D.W. Mount 1982. LexA protein inhibits transcription of the E. coli uvrA gene in vitro. Nature 298:96-98
- Brandsma, J.A., J. Stoorvogel, C.A. Van Sluis, P. Van de Putte 1982. Effect of lexA and ssb genes, present on a uvrA recombinant plasmid, on the UV survival of Escherichia coli K-12. Gene 18:77-85
- Sancar, A., W.D. Rupp 1983. A novel repair enzyme UVRABC excision nuclease of Escherichia coli cuts a DNA strand on both sides of the damaged region. Cell 33:249-260
- Husain, I., B. Van Houten, D.C. Thomas, A. Sancar 1986. Sequences of Escherichia coli urvA gene and protein reveal two potential ATP binding sites. J.Biol.Chem. 261:4895-4901
- Tomer, G., O. Cohen-Fix, M.A. O'Donnell, M. Goodman, Z. Livneh 1996. Reconstitution of repair-gap UV mutagenesis with purified proteins from Escherichia coli: a role for DNA polymerases III and II. Proc.Natl.Acad.Sci.USA 93:1376-1380
- Sancar, A. 1996. DNA excision repair. Annu.Rev.Biochem. 65:43-81
- Linton, K.J., C.F. Higgins 1998. The Escherichia coli ATP-binding cassette (ABC) proteins. Mol.Microbiol. 28:5-13
- Moolenaar, G.F., V. Monaco, G.A. van der Marel, J.H. van Boom, R. Visse, N. Goosen 2000. The effect of the DNA flanking the lesion on formation of the UvrB-DNA preincision complex.Mechanism for the UvrA-mediated loading of UvrB onto a DNA damaged site.
- Goosen, N., G.F. Moolenaar 2001. Role of ATP hydrolysis by UvrA and UvrB during nucleotide excision repair. Res.Microbiol. 152:401-409