Site oxyR
- Name: oxyR
- Type: Gene
- Synonyms
b3961 MG1655 locus tag momR mor - Mnemonic: oxygen
- Left End Point: 89.59
- Right End Point: 89.61
- Products:
peroxide response regulator - Direction: >
- Properties:
Property Comment encodes bifunctional protein NULL regulatory gene NULL - Priority: 0
- 2 Alleles of This Gene
oxyR749(del)::kan oxyR791-YFP(::cat) - External Database Links:
Host Site Page Links NCBI/GenBank J04553 EcoGene.org EG10681 EcoliWiki oxyR - Comment:
- NEW. post-'90. sensor for oxidative stress and activator for genes that detoxify oxidants
- References:
- Tartaglia, L.A., G. Storz, B.N. Ames 1989. Identification and molecular analysis of oxyR-regulated promoters important for the bacterial adaptation to oxidative stress. J.Mol.Biol. 210:709-719
- Tao, K., K. Makino, S. Yonei, A. Nakata, H. Shinagawa 1989. Molecular cloning and nucleotide sequencing of oxyR, the positive regulatory gene of a regulon for an adaptive response to oxidative stress in Escherichia coli: homologies between OxyR protein
- Storz, G., L.A. Tartaglia, B.N. Ames 1990. OxyR, a transcriptional regulator of oxidative stress-inducible genes: direct activation by oxidation. Science 248:189-194
- Kullik, I., J. Stevens, M.B. Toledano, G. Storz 1995. Mutational analysis of the redox-sensitive transcriptional regulator OxyR: regions important for DNA binding and multimerization. J.Bacteriol. 177:1285-1291
- Kullik, I., M.B. Toledano, L.A. Tartaglia, G. Storz 1995. Mutational analysis of the redox-sensitive transcriptional regulator OxyR: regions important for oxidation and transcriptional activation. J.Bacteriol. 177:1275-1284
- Mukhopadhyay, S., H.E. Schellhorn 1997. Identification and characterization of hydrogen peroxide-sensitive mutants of Escherichia coli: genes that require OxyR for expression. J.Bacteriol. 179:330-338
- Gonzalez-Flecha, B., B. Demple 1997. Transcriptional regulation of the Escherichia coli oxyR gene as a function of cell growth. J.Bacteriol. 179:6181-6186
- Henderson, I.R., M. Meehan, P. Owen 1997. A novel regulatory mechanism for a novel phase-variable outer membrane protein of Escherichia coli. Adv. Exp.Med. Biol. 412:349-355
- Zheng, M., G. Storz 1998. Activation of the OxyR transcription factor by reversible disulfide bond formation [see comments]. Science 279:1718-1721
- Zheng, M., B. Doan, T.D. Schneider, G. Storz 1999. OxyR and SoxRS regulation of fur. J.Bacteriol. 181:4639-4643
- Zheng, M., X. Wang, L.J. Templeton, D.R. Smulski, R.A. LaRossa, G. Storz 2001. DNA microarray-mediated transcriptional profiling of the Escherichia coli response to hydrogen peroxide. J.Bacteriol. 183:4562-4570