Site mdlA
- Name: mdlA
- Type: Gene
- Synonyms
b0448 MG1655 locus tag - Mnemonic: multi-drug resistance-like
- Left End Point: 10.09
- Right End Point: 10.13
- Direction: >
- Properties:
Property Comment member of Rob regulon expressed, fctn.unchar'd overexpr. failed to show resistance to antibiotics tested - Priority: 0
- 2 Alleles of This Gene
mdlA734(del)::kan mdlA791-YFP(::cat) - External Database Links:
Host Site Page Links NCBI/GenBank L08627 EcoGene.org EG11622 EcoliWiki mdlA - Comment:
- mdlA and mdlB are putative ABC transporter ORFs but over-expression does not confer drug resistance
- References:
- Allikmets, R., B. Gerrard, D.L. Court, M. Dean 1993. Cloning and organization of the abc and mdl genes of Escherichia coli: relationship to eukaryotic multidrug resistance. Gene 136:231-236
- Nishino, K., A. Yamaguchi 2001. Overexpression of the response regulator evgA of the two-component signal transduction system modulates multidrug resistance conferred by multidrug resistance transporters. J.Bacteriol. 183:1455-1458
- Kobayashi, N., K. Nishino, A. Yamaguchi 2001. Novel macrolide-specific ABC-type efflux transporter in Escherichia coli. J.Bacteriol. 183:5639-5644