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Site seqA
- Name: seqA
- Type: Gene
- Synonyms
b0687 MG1655 locus tag - Mnemonic: sequestration
- Left End Point: 15.35
- Right End Point: 15.36
- Products:
negative regulator of replication initiation - Direction: >
- Properties:
Property Comment DNA biosynthesis NULL regulatory gene modulates replication initiation at oriC and sequestration, ensuring rep.init. once per chr. per cell cycle. - Priority: 0
- 2 Alleles of This Gene
seqA735(del)::kan seqA791-YFP(::cat) - External Database Links:
Host Site Page Links EcoGene.org EG12197 EcoliWiki seqA - Comment:
- References:
- Lu, M., J.L. Campbell, E. Boye, N. Kleckner 1994. SeqA: a negative modulator of replication initiation in E. coli. Cell 77:413-426
- Baker, T.A. 1994. Replication initiation. A new controller in Escherichia coli. Curr.Biol. 4:945-946
- von Freiesleben, U., K.V. Rasmussen, M. Schaechter 1994. SeqA limits DnaA activity in replication from oriC in Escherichia coli. Mol.Microbiol. 14:763-772
- Crooke, E. 1995. Regulation of chromosomal replication in E.coli: sequestration and beyond. Cell 82:877-880
- Slater, S., S. Wold, M. Lu, E. Boye, K. Skarstad, N. Kleckner 1995. E.coli SeqA protein binds oriC in two different methyl-modulated reactions appropriate to its roles in DNA replication initiation and origin sequestration. Cell 82:927-0
- Boye, E., T. Stokke, N. Kleckner, K. Skarstad 1996. Coordinating DNA replication initiation with cell growth: differential roles for DnaA and SeqA proteins. Proc.Natl.Acad.Sci.USA 93:12206-12211