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Site pyrF
- Name: pyrF
- Type: Gene
- Synonyms
b1281 MG1655 locus tag URA-3 yeast gene nomenclature - Mnemonic: Pyrimidine
- Left End Point: 28.88
- Right End Point: 28.90
- Products:
orotidine-5'-phosphate decarboxylase OMP deC'ase - Direction: >
- Properties:
Property Comment auxotrophy-pur/pyr NULL - Priority: 1
- 11 Alleles of This Gene
pyrF101 pyrF11 pyrF111 pyrF267 pyrF287 pyrF30 pyrF32 pyrF40 pyrF789(del)::kan pyrF79::Mu pyrF92 - External Database Links:
Host Site Page Links NCBI/GenBank J02768 EcoGene.org EG10809 EcoliWiki pyrF - Comment:
- Selectable phenotype. Loss: 5-fluoroorotate resistance.
- References:
- Donovan, W.P., S.R. Kushner 1983. Cloning and physical analysis of the pyrF gene (coding for orotidine-5'-phosphate decarboxylase) from Escherichia coli K-12. Gene 25:39-48
- Boeke, J., F. LaCroute, G.R. Fink 1984. A positive selection for mutants lacking orotidine-5'-phosphate decarboxylase activity in yeast: 5-fluoro-orotic acid resistance. Mol.Gen.Genet. 197:345-346
- Jensen, K.F., J.N. Larsen, L. Schack, A. Sivertsen 1984. Studies on the structure and expression of Escherichia coli pyrC, pyrD and pyrF using the cloned genes. Eur.J.Biochem. 140:343-352
- Turnbough, C.L., K.H. Kerr, W.R. Funderburg, J.P. Donahue, F.E. Powell 1987. Nucleotide sequence and characterization of the pyrF operon of Escherichia coli K-12. J.Biol.Chem. 262:10239-10245