Site parE
- Name: parE
- Type: Gene
- Synonyms
b3030 MG1655 locus tag nfxD Breines et al. for quinolone resistance - Mnemonic: partition
- Left End Point: 68.36
- Right End Point: 68.40
- Products:
topoisomerase IV subunit - Direction: <
- Priority: 0
- 1 Alleles of This Gene
parE793-YFP(::cat) - External Database Links:
Host Site Page Links EcoGene.org EG10687 EcoliWiki parE - Comment:
- Topo IV unlinks daughter replicons. nfsC alleles are resistant to high levels of quinolone
- References:
- Kato, J., Y. Nishimura, R. Imamura, H. Niki, S. Hiraga, H. Suzuki 1990. New topoisomerase essential for chromosome segregation in E. coli. Cell 63:393-404
- Kato, J., H. Suzuki, H. Ikeda 1992. Purification and characterization of DNA topoisomerase IV in Escherichia coli. J.Biol.Chem. 267:25676-25684
- Peng, H., K.J. Marians 1993. Escherichia coli topoisomerase IV. Purification, characterization, subunit structure, and subunit interactions. J.Biol.Chem. 268:24481-24490
- Zechiedrich, E.L., N.R. Cozzarelli 1995. Roles of topoisomerase IV and DNA gyrase in DNA unlinking during replication in Escherichia coli. Genes Dev. 9:2859-2869
- Khodursky, A.B., E.L. Zechiedrich, N.R. Cozzarelli 1995. Topoisomerase IV is a target of quinolones in Escherichia coli. Proc.Natl.Acad.Sci.USA 92:11801-11805
- Peng, H., K.J. Marians 1995. The interaction of Escherichia coli topoisomerase IV with DNA. J.Biol.Chem. 270:25286-25290
- Breines, D.M., S. Ouabdesselam, E.Y. Ng, J. Tankovic, S. Shah, C.J. Soussy, D.C. Hooper 1997. Quinolone resistance locus nfxD of Escherichia coli is a mutant allele of the parE gene encoding a subunit of topoisomerase IV. Antimicrob.Agents Chemother. 4
- Levine, C., K.J. Marians 1998. Identification of dnaX as a high-copy suppressor of the conditional lethal and partition phenotypes of the parE10 allele. J.Bacteriol. 180:1232-1240
- Zechiedrich, E.L., A.B. Khodursky, S. Bachellier, R. Schneider, D. Chen, D.M. Lilley, N.R. Cozzarelli 2000. Roles of topoisomerases in maintaining steady-state DNA supercoiling in Escherichia coli. J.Biol.Chem. 275:8103-8113