Site prfC
- Name: prfC
- Type: Gene
- Synonyms
b4375 MG1655 locus tag tos transposon-induced opal suppressor - Mnemonic: protein release factor
- Left End Point: 99.31
- Right End Point: 99.34
- Products:
release factor 3 RF-3 RF3 - Direction: >
- Priority: 0
- 2 Alleles of This Gene
prfC770(del)::kan prfC792-YFP(::cat) - External Database Links:
Host Site Page Links EcoGene.org EG12114 EcoliWiki prfC - Comment:
- sequence homology to EF-G. Stimulates termination. Insertion mutants enhance nonsense suppression.
- References:
- Mikuni, O., K. Ito, J. Moffat, K. Matsumura, K. McCaughan, T. Nobukuni, W. Tate, Y. Nakamura 1994. Identification of the prfC gene, which encodes peptide-chain-release factor 3 of Escherichia coli. Proc.Natl.Acad.Sci.USA 91:5798-5802
- Grentzmann, G., D. Brechemier-Baey, V. Heurgue, L. Mora, R.H. Buckingham 1994. Localization and characterization of the gene encoding release factor RF3 in Escherichia coli. Proc.Natl.Acad.Sci.USA 91:5848-5852
- Matsumura, K., K. Ito, Y. Kawazu, O. Mikuni, Y. Nakamura 1996. Suppression of temperature-sensitive defects of polypeptide release factors RF-1 and RF-2 by mutations or by an excess of RF-3 in Escherichia coli. J.Mol.Biol. 258:588-599
- Yanofsky, C., V. Horn, Y. Nakamura 1996. Loss of overproduction of polypeptide release factor 3 influences expression of the tryptophanase operon of Escherichia coli. J.Bacteriol. 178:3755-3762
- Pavlov, M.Y., D.V. Freistroffer, J. MacDougall, R.H. Buckingham, M. Ehrenberg 1997. Fast recycling of Escherichia coli ribosomes requires both ribosome recycling factor (RRF) and release factor RF3 [published erratum appears in EMBO J 1997 Sep 1;16(17)
- Heurgue-Hamard, V., R. Karimi, L. Mora, J. MacDougall, C. Leboeuf, G. Grentzmann, M. Ehrenberg, R.H. Buckingham 1998. Ribosome release factor RF4 and termination factor RF3 are involved in dissociation of peptidyl-tRNA from the ribosome. EMBO J. 17:808