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Site mcrB
- Name: mcrB
- Type: Gene
- Synonyms
b4346 MG1655 locus tag rglB - Mnemonic: methylcytosine restriction
- Left End Point: 98.63
- Right End Point: 98.66
- Products:
restriction endonuclease at 5-methylcytosine residues McrBC - Direction: <
- Priority: 1
- 5 Alleles of This Gene
mcrB1 mcrB2222 mcrB744(del)::kan mcrB791-YFP(::cat) mcrB9999 - External Database Links:
Host Site Page Links EcoGene.org EG10574 EcoliWiki mcrB - Comment:
- restriction of DNA at 5-methyl cytosine residues
- References:
- Raleigh, E.A., G. Wilson 1986. Escherichia coli K-12 restricts DNA containing 5-methylcytosine. Proc.Natl.Acad.Sci.USA 83:9070-9074
- Ross, T.K., H.D. Braymer 1987. Localization of a genetic region involved in McrB restriction by Escherichia coli K-12. J.Bacteriol. 169:1757-1759
- Ross, T.K., C. Achberger, H.D. Braymer 1987. Characterization of the Escherichia coli modified cytosine restriction (mcrB) gene. Gene 61:277-289
- Raleigh, E.A., R. Trimarchi, H. Revel 1989. Genetic and physical mapping of the mcrA (rflA) and mcrB (rglB) loci of Escherichia coli K-12. Genetics 122:279-296
- Ross, T.K., E.C. Achberger, H.D. Braymer 1989. Nucleotide sequence of the McrB region of Escherichia coli K-12 and evidence for two independent translational initiation sites at the mcrB locus. J.Bacteriol. 171:1974-1981
- Dila, D., E. Sutherland, L. Moran, B. Slatko, E.A. Raleigh 1990. Genetic and sequence organization of the mcrBC locus of Escherichia coli K-12. J.Bacteriol. 172:4888-4900
- Raleigh, E.A., J. Benner, P. Bloom, H.D. Braymer, E. DeCruz, K. Dharmalingam, J. Heitman, M. Noyer Weidner, A. Piekarowicz, P. Kretz, et al 1991. Nomenclature relating to restriction of modified DNA in Escherichia coli. J.Bacteriol. 173:2707-2709
- Kruger, T., C. Grund, C. Wild, M. Noyer-Weidner 1992. Characterization of the mcrBC region of Escherichia coli K-12 wild-type and mutant strains. Gene 114:1-12
- Pieper, U., A. Pingoud 2002. A mutational analysis of the PD...D/EXK motif suggests that McrC harbors the catalytic center for DNA cleavage by the GTP-dependent restriction enzyme McrBC from Escherichia coli. Biochemistry 41:5236-5244