Site metL
- Name: metL
- Type: Gene
- Synonyms
b3940 MG1655 locus tag metM - Mnemonic: Methionine
- Left End Point: 88.97
- Right End Point: 89.02
- Products:
aspartokinase II-homoserine dehydrogenase II - Direction: >
- Properties:
Property Comment auxotrophy-amino acid NULL - Priority: 1
- 5 Alleles of This Gene
metL1000 metL1004 metL1005 metL727(del)::kan metL795-YFP(::cat) - External Database Links:
Host Site Page Links NCBI/GenBank J01651 NCBI/GenBank V00305 EcoGene.org EG10590 EcoliWiki metL - Comment:
- Selectable phenotype. FBI-: B-hydroxynorvaline resistance.
- References:
- Cohen, G.N., J.C. Patte, P. Truffa-Bachi, C. Sawas, M. Doudoroff 1965. Repression and end-product inhibition in a branched biosynthetic pathway, p. 243-253. In Mecanismes de regulation des activities cellulaires chez les micro-organismes. Centre Nation
- Dautry-Varsat, A., A.L. Sibilli-Weil, G.N. Cohen 1977. Subunit structure of the methionine-repressible aspartokinase II-homoserine dehydrogenase II from Escherichia coli K12. Eur.J.Biochem. 76:1-6
- Krueger, J.H., J.R. Johnson, R.C. Greene, M. Dresser 1981. Structural studies of lambda transducing bacteriophage carrying bacterial deoxyribonucleic acid from the metBJLF region of the Escherichia coli chromosome. J.Bacteriol. 147:612-621
- Zakin, M.M., R.C. Greene, A. Dautry-Varsat, N. Duchange, P. Ferrara, M.-C. Py, D. Margarita, G.N. Cohen 1982. Construction and physical mapping of plasmids containing the metJBLF gene cluster of Escherichia coli K12. Mol.Gen.Genet. 187:101-106
- Greene, R.C., J.H. Krueger, J.R. Johnson 1982. Localization of the metJBLF gene cluster of Escherichia coli in LAMmet transducing phage. Mol.Gen.Genet. 187:401-404
- Duchange, N., M.M. Zakin, P. Ferrara, I. Saint-Girons, I. Park, S.V. Tran, M.-C. Py, G.N. Cohen 1983. Structure of the metJBLF cluster in Escherichia coli K12. Sequence of the metB structural gene of the 5'- and 3'-flanking regions of the metBL operon.
- Zakin, M.M., N. Duchange, P. Ferrara, G.N. Cohen 1983. Nucleotide sequence of the metL gene of Escherichia coli. Its product, the bifunctional aspartokinase II-homoserine dehydrogenase II, and the bifunctional product of the thrA gene, aspartokinase I
- Saint-Girons, I., N. Duchange, G.N. Cohen, M.M. Zakin 1984. Structure and autoregulation of the metJ regulatory gene in Escherichia coli. J.Biol.Chem. 259:14282-14285
- Greene, R.C., A.A. Smith 1984. Insertion mutagenesis of the metJBLF gene cluster of Escherichia coli K-12: evidence for a metBL operon. J.Bacteriol. 159:767-769
- Kirby, T.W., B.R. Hindenach, R.C. Greene 1986. Regulation of in vivo transcription of the Escherichia coli K-12 metJBLF gene cluster. J.Bacteriol. 165:671-677