Site hlyE
- Name: hlyE
- Type: Gene
- Synonyms
b1182 MG1655 locus tag clyA Ludwig et al., Oscarsson et al. sheA del Castillo et al (1997) ycgD - Mnemonic: hemolysin (latent)
- Left End Point: 26.49
- Right End Point: 26.50
- Products:
latent hemolysin - Direction: <
- Priority: 0
- 1 Alleles of This Gene
hlyE771(del)::kan - External Database Links:
Host Site Page Links EcoGene.org EG13243 EcoliWiki hlyE - Comment:
- Actinobacillus hlyX-expressing K-12 produce this otherwise latent hemolysin. Also mutant fnr's will result in expression. Overexpression of hlyE (sheA) will result in hemolytic phenotype.
- References:
- Holland, I.B., B. Kenny, M. Blight 1990. Haemolysin secretion from E. coli. Biochimie 72:131-141
- Green, J., M.L. Baldwin 1997. The molecular basis for the differential regulation of the hlyE-encoded haemolysin of Escherichia coli by FNR and HlyX lies in the improved activating region 1 contact of HlyX. Microbiology 143:3785-3793
- del Castillo, F.J., S.C. Leal, F. Moreno, I. del Castillo 1997. The Escherichia coli K-12 sheA gene encodes a 34-kDa secreted haemolysin. Mol.Microbiol. 25:107-115
- Ludwig, A., S. Bauer, R. Benz, B. Bergmann, W. Goebel 1999. Analysis of the SlyA-controlled expression, subcellular localization and pore-forming activity of a 34 kDa haemolysin (ClyA) from Escherichia coli K-12. Mol.Microbiol. 31:557-567
- Oscarsson, J., Y. Mizunoe, L. Li, X.H. Lai, A. Wieslander, B.E. Uhlin 1999. Molecular analysis of the cytolytic protein ClyA (SheA) from Escherichia coli. Mol.Microbiol. 32:1226-1238
- Lai, X.H., I. Arencibia, A. Johansson, S.N. Wai, J. Oscarsson, S. Kalfas, K.G. Sundqvist, Y. Mizunoe, A. Sjostedt, B.E. Uhlin 2000. Cytocidal and apoptotic effects of the ClyA protein from Escherichia coli on primary and cultured monocytes and macropha
- del Castillo, F.J., F. Moreno, I. del Castillo 2001. Secretion of the Escherichia coli K-12 SheA hemolysin is independent of its cytolytic activity. FEMS Microbiol.Lett. 204:281-285