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Site lrp
- Name: lrp
- Type: Gene
- Synonyms
b0889 MG1655 locus tag ihb Tuan et al. 1990 livR pre-1990 studies lrs Ursini et al. lss lstR mbf methylation-blocking factor oppI rblA R.T.Lin et al., 1990 - Mnemonic: leucine-responsive regulatory protein
- Left End Point: 20.09
- Right End Point: 20.10
- Products:
high-affinity branched-chain amino acid transport system; regulatory gene; repressor protein leucine-responsive regulatory protein - Direction: >
- Properties:
Property Comment global regulation reg.incl.ilvIH,serA,tdh,sdaA,oppABCD,livJ,livKHMGF,papBA,fanABC,fim,lysU,lrp,ompF,ompC,gltD,(pap) - Priority: 1
- 2 Alleles of This Gene
lrp-1 lrp-787(del)::kan - External Database Links:
Host Site Page Links EcoGene.org EG10547 EcoliWiki lrp - Comment:
- Selectable phenotype. In leu-: use of D-leucine. Lrp, a transcriptional activator of phase-ON cells and repressor of basal transcr. in phase-OFF.
- References:
- Anderson, J.J., S.C. Quay, D.L. Oxender 1976. Mapping of two loci affecting the regulation of branched-chain amino acid transport in Escherichia coli K-12. J.Bacteriol. 126:80-90
- Ursini, M.V., P. Arcari, M. De Felice 1981. Acetohydroxy acid synthetase isoenzymes of Escherichia coli K-12; a trans-acting regulatory locus for ilvH1 gene expression. Mol.Gen.Genet. 181:491-496
- Antonucci, T.K., M. Wagner, D.L. Oxender 1986. Cloning, expression, and nucleotide sequence of livR, the repressor for high-affinity branched-chain amino acid transport in Escherichia coli. Proteins Struct.Funct. 1:125-133
- Platko, J.V., D.A. Willins, J.M. Calvo 1990. The ilvIH operon of Escherichia coli is positively regulated. J.Bacteriol. 172:4563-4570
- Tuan, L.R., R. D'Ari, E.B. Newman 1990. The leucine regulon of Escherichia coli K-12: a mutation in rblA alters expression of L-leucine-dependent metabolic operons. J.Bacteriol. 172:4529-4535
- Willins, D.A., C.W. Ryan, J.M. Calvo 1991. Characterization of Lrp, an Escherichia coli regulatory protein that mediates a global response to leucine. J.Biol.Chem. 266:10768-10774
- Gazeau, M., F. Delort, P. Dessen, S. Blanquet, P. Plateau 1992. Escherichia coli leucine-responsive regulatory protein (Lrp) controls lysyl-tRNA synthetase expression. FEBS Lett. 300:254-258
- Newman, E.B., R. D'Ari, R.T. Lin 1992. The leucine-Lrp regulon in E. coli: a global response in search of a raison d'etre. Cell 68:617-619
- Lin, R., B. Ernsting, I.N. Hirshfield, R.G. Matthews, F.C. Neidhardt, R.L. Clark, E.B. Newman 1992. The lrp gene product regulates expression of lysU in Escherichia coli K-12. J.Bacteriol. 174:2779-2784
- Braaten, B.A., J.V. Platko, M.W. van der Woude, B.H. Simons, F.K. de Graaf, J.M. Calvo, D.A. Low 1992. Leucine-responsive regulatory protein controls the expression of both the pap and fan pili operons in Escherichia coli. Proc.Natl.Acad.Sci.USA 89:425
- Haney, S.A., J.V. Platko, D.L. Oxender, J.M. Calvo 1992. Lrp, a leucine-responsive protein, regulates branched-chain amino acid transport genes in Escherichia coli. J.Bacteriol. 174:108-115
- Smith, D.W., W.B. Stine, A.L. Svitil, A. Bakker, J.W. Zyskind 1992. Escherichia coli cells lacking methylation-blocking factor (leucine-responsive regulatory protein) have precise timing of initiation of DNA replication in the cell cycle. J.Bacteriol.
- D'Ari, R., R.T. Lin, E.B. Newman 1993. The leucine-responsive regulatory protein: more than a regulator?. Trends Biochem.Sci. 18:260-263
- Gally, D.L., T.J. Rucker, I.C. Blomfield 1994. The Leucine-responsive regulatory protein binds to the fim switch to control phase variation of Type 1 fimbrial expression in Escherichia coli K-12. J.Bacteriol. 176:5665-5672
- van der Woude, M.W., L.S. Kaltenbach, D.A. Low 1995. Leucine-responsive regulatory protein plays dual roles as both an activator and a repressor of the Escherichia coli pap fimbrial operon. Mol.Microbiol. 17:303-312
- Cui, Y., Q. Wang, G.D. Stormo, J.M. Calvo 1995. A consensus sequence for binding of Lrp to DNA. J.Bacteriol. 177:4872-4880
- Newman, E.B., R. Lin 1995. Leucine-responsive regulatory protein: a global regulator of gene expression in E. coli. Annu.Rev.Microbiol. 49:747-775
- Friedberg, D., J.V. Platko, B. Tyler, J.M. Calvo 1995. The amino acid sequence of Lrp is highly conserved in four enteric microorganisms. J.Bacteriol. 177:1624-1626
- Landini, P., L.I. Hajec, L.H. Nguyen, R.R. Burgess, M.R. Volkert 1996. The leucine-responsive regulatory protein (Lrp) acts as a specific repressor for sigma s-dependent transcription of the Escherichia coli aidB gene. Mol.Microbiol. 20:947-955
- Rhee, K.Y., B.S. Parekh, G.W. Hatfield 1996. Leucine-responsive regulatory protein-DNA interactions in the leader region of the ilvGMEDA operon of Escherichia coli. J.Biol.Chem. 271:26499-26507
- Roesch, P.L., I.C. Blomfield 1998. Leucine alters the interaction of the leucine-responsive regulatory protein (Lrp) with the fim switch to stimulate site-specific recombination in Escherichia coli. Mol.Microbiol. 27:751-761
- Chen, C., E.B. Newman 1998. Comparison of the sensitivities of two Escherichia coli genes to in vivo variation of Lrp concentration. J.Bacteriol. 180:655-659