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Site tyrR
- Name: tyrR
- Type: Gene
- Synonyms
b1323 MG1655 locus tag - Mnemonic: Tyrosine
- Left End Point: 29.85
- Right End Point: 29.88
- Products:
TyrR repressor - Direction: >
- Properties:
Property Comment encodes NA-binding protein recog.palindrome,TyrR box, usually overlapping RNAP-binding site. member of TyrR regulon (auto-regul. repress. not med. by Tyr, single TyrR box - Priority: 1
- 4 Alleles of This Gene
tyrR352 tyrR366 tyrR760(del)::kan tyrR792-YFP(::cat) - External Database Links:
Host Site Page Links NCBI/GenBank M12114 EcoGene.org EG11042 EcoliWiki tyrR - Comment:
- Selectable phenotype. tyr^c: 4-aminophenylalanine resistance; fluorotyrosine resistance. usually req.tyr and ATP to bind to second TyrR box and repress. Related to NtrC family.
- References:
- Wallace, B.J., J. Pittard 1969. Regulator gene controlling enzymes concerned in tyrosine biosynthesis in Escherichia coli. J.Bacteriol. 97:1234-1241
- Mattern, I.E., J. Pittard 1971. Regulation of tyrosine biosynthesis in Escherichia coli K-12: isolation and characterization of operator mutants. J.Bacteriol. 107:8-15
- Brown, K.D., R.L. Somerville 1971. Repression of aromatic amino acid biosynthesis in Escherichia coli K12. J.Bacteriol. 108:386-399
- Chippaux, M., D. Giudici, A. Abou-Jaoude, F. Casse, M.C. Pascal 1978. A mutation leading to the total lack of nitrate reductase activity in Escherichia coli K-12. Mol.Gen.Genet. 160:225-229
- Cobbett, C.S., J. Pittard 1980. Formation of a lambda (Tn10) tyrR+ specialized transducing bacteriophage from Escherichia coli K-12. J.Bacteriol. 144:877-883
- Wild, J.R., T. Klopotowski 1981. D-amino acid dehydrogenase of Escherichia coli K12: positive selection of mutants defective in enzyme activity and localization of the structural gene. Mol.Gen.Genet. 181:373-378
- Camakaris, H., J. Pittard 1982. Autoregulation of the tyrR gene. J.Bacteriol. 150:70-75
- Cornish, E.C., B.E. Davidson, J. Pittard 1982. Cloning and characterization of Escherichia coli K-12 regulator gene tyrR. J.Bacteriol. 152:1276-1279
- Cornish, E.C., V.P. Argyropoulos, J. Pittard, B.E. Davidson 1986. Structure of the Escherichia coli K12 regulatory gene tyrR: nucleotide sequence and sites of initiation of transcription and translation. J.Biol.Chem. 261:403-410
- Pittard, A.J., B.E. Davidson 1991. TyrR protein of Escherichia coli and its role as repressor and activator. Mol.Microbiol. 5:1585-1592
- Cui, J., R.L. Somerville 1992. Physical map location and transcriptional orientation of the tyrR gene of Escherichia coli K-12. J.Bacteriol. 174:3832-3833
- Yang, J., H. Camakaris, A.J. Pittard 1993. Mutations in the tyrR gene of Escherichia coli which affect TyrR-mediated activation but not TyrR-mediated repression. J.Bacteriol. 175:6372-6375
- Cui, J., R.L. Somerville 1993. A mutational analysis of the structural basis for transcriptional activation and monomer-monomer interaction in the TyrR system of Escherichia coli. J.Bacteriol. 175:1777-1784
- Yang, J., S. Ganesan, J.P. Sarsero, A.J. Pittard 1993. A genetic analysis of various functions of the TyrR protein of Escherichia coli. J.Bacteriol. 175:1767-1776
- Lawley, B., J. Pittard 1994. Regulation of aroL expression by TyrR protein and Trp repressor in Escherichia coli K-12. J.Bacteriol. 176:6921-6930
- Gowrishankar, J., A.J. Pittard 1998. Superimposition of tyrR protein-mediated regulation on osmoresponsive transcription of Escherichia coli proU in vivo. J.Bacteriol. 180:6743-6748
- Hwang, J.S., J. Yang, A.J. Pittard 1999. Specific contacts between residues in the DNA-binding domain of the TyrR protein and bases in the operator of the tyrP gene of Escherichia coli. J.Bacteriol. 181:2338-2345