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Site lacI
- Name: lacI
- Type: Gene
- Synonyms
b0345 MG1655 locus tag - Mnemonic: Lactose
- Left End Point: 7.88
- Right End Point: 7.91
- Direction: <
- Priority: 1
- 11 Alleles of This Gene
lacI100 lacI203 lacI22 lacI3042::Tn10 lacI3098::Tn10kan lacI373 lacI4500::Tn10 lacI50(Fs) lacI60 lacI694(I$^S$) lacI785(del)::kan - External Database Links:
Host Site Page Links EcoGene.org EG10525 EcoliWiki lacI - Comment:
- Sel.phen. Constit. exp. of lacZ,Y,A: growth on a-methylglycoside+lactose;growth on raffinose, neolactose, phenylgalactoside, lactobionic acid, lactitol, melibiose or w/ N-acetyllactonate as nit.srce.
- References:
- Lester, B., D.M. Bonner 1957. Genetic control of raffinose utilization in Escherichia coli. J.Bacteriol. 73:544-552
- Kessler, D.P., H.V. Rickenberg 1964. A new method for the selection of mutants of Escherichia coli forming beta-galactosidase constitutively. Biochim.Biophys.Acta 90:609-610
- Loomis, W.F., B. Magasanik 1965. Genetic control of catabolite repression of the lac operon in Escherichia coli. Biochem.Biophys.Res.Commun. 20:230-234
- Loomis, W.F., B. Magasanik 1967. The catabolite repression gene of the lac operon in Escherichia coli. J.Mol.Biol. 23:487-494
- Muller-Hill, B., L. Crapo, W. Gilbert 1968. Mutants that make more lac repressor. Proc.Natl.Acad.Sci.USA 59:1259-1264
- Langridge, J. 1969. Mutations conferring quantitative and qualitative increases in beta-galactosidase activity in Escherichia coli. Mol.Gen.Genet. 105:74-83
- Smith, T.F., J.R. Sadler 1971. The nature of lactose operator constitutive mutations. J.Mol.Biol. 59:273-305
- Beyreuther, K., K. Adler, E. Fanning, C. Murray, A. Klemm, N. Geisler 1975. Amino-acid sequence of lac repressor from Escherichia coli.Isolation, sequence analysis and sequence assembly of tryptic peptides and cyanogen-bromide fragments. Eur.J.Biochem.
- Norwood, W.I., J.R. Sadler 1977. Pseudoreversion of lactose operator-constitutive mutants. J.Bacteriol. 130:100-106
- Farabaugh, P.J. 1978. Sequence of the lacI gene. Nature 274:765-769
- Lengeler, J.W., H. Steinberger 1978. Analysis of the regulatory mechanisms controlling the synthesis of the hexitol transport systems in Escheirchia coli K12. Mol.Gen.Genet. 164:163-169
- Saier, M.H., H. Straud, L.S. Massman, J.J. Judice, M.J. Newman, B.U. Feucht 1978. Permease-specific mutations in Salmonella typhimurium and Escherichia coli that release the glycerol, maltose, melibiose, and lactose transport systems from regulation by
- Calos, M.P., J.H. Miller 1980. DNA sequence alteration resulting from a mutation impairing promoter function in the lac repressor gene. Mol.Gen.Genet. 178:225-227
- Horowitz, H., T. Platt 1982. A termination site for Lac 1 transcription is between the CAP site and the lac promoter. J.Biol.Chem. 257:11740-11746
- Betz, J.L. 1986. Cloning and characterization of several dominant-negative and tight-binding mutants of lac repressor. Gene 42:283-292
- Gordon, A.J., P.A. Burns, D.F. Fix, F. Yatagai, F.L. Allen, M.J. Horsfall, Halliday, Ja, J. Gray, C. Bernelot-Moens, B.W. Glickman 1988. Missense mutation in the lacI gene of Escherichia coli. Inferences on the structure of the repressor protein. J.Mol
- Markiewicz, P., L.G. Kleina, C. Cruz, S. Ehret, J.H. Miller 1994. Genetic studies of the lac repressor. XIV. Analysis of 4000 altered Escherichia coli lac repressors reveals essential and non-essential residues, as well as "spacers" which do not requi
- Pogliano, J.A., J.R. Beckwith 1994. SecD and SecF facilitate protein export in Escherichia coli. EMBO J. 13:554-561