Site hisF
- Name: hisF
- Type: Gene
- Synonyms
b2025 MG1655 locus tag - Mnemonic: Histidine
- Left End Point: 45.13
- Right End Point: 45.15
- Products:
cyclase component of HISHF (IGP synthase) complex [P-ribulosyl carboxamide intermediate]-glutamine glutaminase and cyclase cyclase of IGP synthase rx. - Direction: >
- Properties:
Property Comment auxotrophy-amino acid NULL - Priority: 1
- 3 Alleles of This Gene
hisF723(del)::kan hisF860(Stable) hisF892 - External Database Links:
Host Site Page Links EcoGene.org EG10448 EcoliWiki hisF - Comment:
- His-consitutives overproducing HisH and HisF yield increased AICAR, also intermed. in pur biosynth. Also leads to filamentation and other morphol.effects, but not due to AICAR.
- References:
- Garrick-Silversmith, L., P.E. Hartman 1970. Histidine-requiring mutants of Escherichia coli K12. Genetics 66:231-244
- Goldschmidt, E.P., M.S. Cater, T.S. Matney, M.A. Butler, A. Greene 1970. Genetic analysis of the histidine operon in Escherichia coli K12. Genetics 66:219-229
- Alifano, P., M.S. Carlomagno, C.B. Bruni 1992. Location of the hisGDCBHAFI operon on the physical map of Escherichia coli. J.Bacteriol. 174:3830-3831
- Frandsen, N., R. D'Ari 1993. Excess histidine enzymes cause AICAR-independent filamentation in Escherichia coli. Mol.Gen.Genet. 240:348-354
- Klem, T.J., V.J. Davisson 1993. Imidazole glycerol phosphate synthase: the glutamine amidotransferase in histidine biosynthesis. Biochemistry 32:5177-5186
- Fani, R., P. Lio, I. Chiarelli, M. Bazzicalupo 1994. The evolution of the histidine biosynthetic genes in prokaryotes: a common ancestor for the hisA and hisF genes. J.Mol.Evol. 38:489-495
- Flores, A., J. Casadesus 1995. Suppression of the pleiotropic effects of HisH and HisF overproduction identifies four novel loci on the Salmonella typhimurium chromosome: osmH, sfiW, sfiX, and sfiY. J.Bacteriol. 177:4841-4850