E. coli Genetic Resources at Yale
CGSC, The Coli Genetic Stock Center

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Site ispE

• Name: ispE
• Type: Gene
  Synonyms

  b1208	MG1655 locus tag
  IPK gene	Lange and Croteau
  ychB	temporary name, sequence

  
  
• Mnemonic: isoprenoid synthesis
• Left End Point: 27.19
• Right End Point: 27.20
  Products:

  isopentenyl monophosphate kinase

  4-diphosphocytidyl-2C-methyl-D-erythritol kinase

  
  
• Direction: <
• Priority: 0
  1 Alleles of This Gene

  ispE792-YFP(::cat)

  
  
• External Database Links:

  Host Site	Page Links
  EcoGene.org	EG11294
  EcoliWiki	ispE

  
  
• Comment:
  • deoxyxylulose-5-P (mevalonate-independent) pathway of isoprenoid biosynthesis. terminal step 2-C-methylerythritol-4-P to isopentenyl diphosphate.
• References:
  • Lange, B.M., R. Croteau 1999. Isopentenyl diphosphate biosynthesis via a mevalonate-independent pathway: isopentenyl monophosphate kinase catalyzes the terminal enzymatic step. Proc.Natl.Acad.Sci.USA 96:13714-13719
  
  
  • Luttgen, H., F. Rohdich, S. Herz, J. Wungsintaweekul, S. Hecht, C.A. Schuhr, M. Fellermeier, S. Sagner, M.H. Zenk, A. Bacher, W. Eisenreich 2000. Biosynthesis of terpenoids: YchB protein of Escherichia coli phosphorylates the 2-hydroxy group of 4-dipho