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Site gyrA
- Name: gyrA
- Type: Gene
- Synonyms
b2231 MG1655 locus tag hisW nalA parD - Mnemonic: Gyrase
- Left End Point: 50.33
- Right End Point: 50.38
- Products:
DNA gyrase, subunit A - Direction: <
- Properties:
Property Comment cold shock response regulon NULL quinolone (nal,ciprofloxacin)R in presence of parC - Priority: 1
- External Database Links:
Host Site Page Links EcoGene.org EG10423 EcoliWiki gyrA - Comment:
- Selectable phenotype. Nalidixic acid resistance; oxolinic acid resistance growth on B-glucosides. In topA-: strong growth. With parC quinolone-resistant (ciprofloxacin)
- References:
- Hane, M.W., T.H. Wood 1969. Escherichia coli K-12 mutants resistant to nalidixic acid: genetic mapping and dominant studies. J.Bacteriol. 99:238-241
- Staudenbauer, W.L. 1976. Replication of Escherichia coli DNA in vitro: inhibition by oxoline acid. J.Biochem.(Tokyo) 62:491-497
- Kreuzer, K.N., N.R. Cozzarelli 1979. Escherichia coli mutants thermosensitive for deoxyribonucleic acid gyrase subunit A: effects on deoxyribonucleic acid replication, transcription, and bacteriophage growth. J.Bacteriol. 140:424-435
- DiNardo, S., K.A. Voelkel, R. Sternglanz, A.E. Reynolds, A. Wright 1982. Escherichia coli DNA topoisomerase I mutants have compensatory mutations in DNA gyrase genes. Cell 31:43-51
- Swanberg, S.L., J.C. Wang 1987. Cloning and sequencing of the Escherichia coli gyrA gene coding for the A subunit of DNA gyrase. J.Mol.Biol. 197:729-736
- Menzel, R., M. Gellert 1987. Modulation of transcription by DNA supercoiling: a deletion analysis of the Escherichia coli gyrA and gyrB promoters. Proc.Natl.Acad.Sci.USA 84:4185-4189
- Menzel, R., M. Gellert 1987. Fusions of the Escherichia coli gyrA and gyrB control regions to the galactokinase gene are inducible by coumermycin treatment. J.Bacteriol. 169:1272-1278
- Hussain, K., E.J. Elliot, G.P.C. Salmond 1987. The parD- mutant of Escherichia coli also carries a gyrA_Am mutation. The complete sequence of gyrA. Mol.Microbiol. 1:259-273
- Yoshida, K., T. Kojima, J.-I. Yamagishi, S. Nakamura 1988. Quinolone-resistant mutations of the gyrA gene of Escherichia coli. Mol.Gen.Genet. 211:1-7
- Nakamura, S., M. Nakamura, T. Kojima, H. Yoshida 1989. gyrA and gyrB mutations in quinolone-resistant strains of Escherichia coli. Antimicrob.Agents Chemother. 33:254-255
- Webb, G., K. Rohatgi, J.B. Courtright 1990. Location of gyrA on the physical map of the Escherichia coli chromosome. J.Bacteriol. 172:6617
- Jones, P.G., R. Krah, S.R. Tafuri, A.P. Wolffe 1992. DNA gyrase, CS7.4, and the cold shock response in Escherichia coli. J.Bacteriol. 174:5798-5802
- Straney, R., R. Krah, R. Menzel 1994. Mutations in the -10 TATAAT sequence of the gyrA promoter affect both promoter strength and sensitivity to DNA supercoiling. J.Bacteriol. 176:5999-6006
- Yonezawa, M., M. Takahata, N. Banzawa, N. Matsubara, Y. Watanabe, H. Narita 1995. Analysis of the NH2-terminal 83rd amino acid of Escherichia coli GyrA in quinolone-resistance. Microbiol.Immunol. 39:243-247
- Heisig, P. 1996. Genetic evidence for a role of parC mutations in development of high-level fluoroquinolone resistance in Escherichia coli. Antimicrob.Agents Chemother. 40:879-885
- Kataoka, K., T. Mizushima, Y. Ogata, T. Miki, K. Sekimizu 1996. Heat shock-induced DNA relaxation in vitro by DNA gyrase of Escherichia coli in the presence of ATP. J.Biol.Chem. 271:24806-24810
- Truong, Q.C., J.C. Nguyen Van, D. Shlaes, L. Gutmann, N.J. Moreau 1997. A novel, double mutation in DNA gyrase A of Escherichia coli conferring resistance to quinolone antibiotics. Antimicrob.Agents Chemother. 41:85-90
- Bagel, S, V Hullen, B Wiedemann, P Heisig 1999. Impact of gyrA and parC mutations on quinolone resistance, doubling time, and supercoiling degree of Escherichia coli. Antimicrob. Agents Chemother. 43(4):868-75.