Site grpE
- Name: grpE
- Type: Gene
- Synonyms
b2614 MG1655 locus tag - Mnemonic: growth after prophage induction
- Left End Point: 59.24
- Right End Point: 59.25
- Products:
GrpE heat shock protein - Direction: <
- Properties:
Property Comment stress response heat shock, autogenously regulated autoregulation of heat shock response - Priority: 1
- 1 Alleles of This Gene
grpE280 - External Database Links:
Host Site Page Links NCBI/GenBank X07863 FlyBase FBgn0014877 EcoGene.org EG10416 EcoliWiki grpE - Comment:
- Selectable phenotype. Survival of induction of mutant LAM prophage. Stimulates DnaK ATPase, nucleotide exchange function
- References:
- Saito, H, H Uchida 1977. Initiation of the DNA replication of bacteriophage lambda in Escherichia coli K12. 113(1):1-25.
- Lipinska, B., J. King, D. Ang, C. Georgopoulos 1988. Sequence analysis and transcriptional regulation of the Escherichia coli grpE gene, encoding a heat shock protein. Nucleic Acids Res. 16:7545-7562
- Straus, D., W. Walter, C.A. Gross 1990. DnaK, DnaJ, and GrpE heat shock proteins negatively regulate heat shock gene expression by controlling the synthesis and stability of sigma 32. Genes Dev. 4:2202-2209
- Shi, W., Y. Zhou, J. Wild, J. Adler, C.A. Gross 1992. DnaK, DnaJ, and GrpE are required for flagellum synthesis in Escherichia coli. J.Bacteriol. 174:6256-6263
- Wu, B., D. Ang, M. Snavely, C. Georgopoulos 1994. Isolation and characerization of point mutations in the Escherichia coli grpE heat shock gene. J.Bacteriol. 176:6965-6973
- Skowyra, D., S. Wickner 1995. GrpE alters the affinity of DnaK for ATP and Mg2+.Implications for the mechanism of nucleotide exchange. J.Biol.Chem. 270:26282-0
- Wu, B., A. Wawrzynow, M. Zylicz, C. Georgopoulos 1996. Structure-function analysis of the Escherichia coli GrpE heat shock protein. EMBO J. 15:4806-4816
- Pierpaoli, E.V., E. Sandmeier, H.J. Schonfeld, P. Christen 1998. Control of the DnaK chaperone cycle by substoichiometric concentrations of the co-chaperones DnaJ and GrpE. J.Biol.Chem. 273:6643-6649